Short term biological variation of common hematological parameters in healthy subjects in a South Asian population.
There is no rigorous publication on the biological variation of common hematological parameters in South Asians to date. Also, there are few publications worldwide dealing with a variation of Reticulocyte parameters. Therefore, an attempt was made to estimate the short term within-subject and betwee...
| Publicado en: | Scandinavian Journal of Clinical & Laboratory Investigation Vol. 80; no. 2; pp. 93 - 99 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142533098&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142533098 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00365513 BD5 jtl: Scandinavian Journal of Clinical & Laboratory Investigation issn: 00365513 maglogo: Y pubinfo: dt: Mar2020 vid: 80 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 142533098 142533098 NLM31829760 142533098 10.1080/00365513.2019.1700424 NLM31829760 142533098 ppf: 93 ppct: 6 formats: tig: atl: Short term biological variation of common hematological parameters in healthy subjects in a South Asian population. aug: au: Gupta, Arvind Kumar Kunnumbrath, Arathi Tayal, Sakshi Garg Kumar, Utpal Bharati, Vandna Anthony, Michael Leonard Singh, Neha Chandra, Harish Chowdhury, Nilotpal affil: Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, India sug: subj: Hematologic Tests Hemoglobins Blood Platelets Reference Values India Middle Age Adult Female Leukocytes Research Subjects Erythrocytes Reticulocytes Young Adult Male Human Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: There is no rigorous publication on the biological variation of common hematological parameters in South Asians to date. Also, there are few publications worldwide dealing with a variation of Reticulocyte parameters. Therefore, an attempt was made to estimate the short term within-subject and between-subject biological variation of common hematological and reticulocyte parameters. Twenty-eight healthy individuals (fifteen males and thirteen females) were selected after clinical and laboratory examination. Blood was collected in K3-EDTA vials in the morning for six consecutive days and analysed in triplicate on the Sysmex XN-1000 analyzer. Outliers were excluded and the within-subject, between-subject and analytical coefficient of variation calculated after statistical analysis by nested repeated measures ANOVA. The Reference change values (RCV), and estimates for desirable imprecision, bias, total error and index of individuality calculated. The within-subject biological variation for the studied subset belonging to South Asia closely followed published European and American studies and were similar for males and females. The between-subject variation showed differences from the published studies for white blood cells, platelets, red blood cells, hemoglobin, platelet indices and reticulocyte hemoglobin as well as between males and females for hemoglobin, red blood cell count and hematocrit. All the indices of individuality were low. This study supports the contention that the conclusions from within-subject biological variation for common hematological parameters are important and transportable to a South Asian population for short-term serial measurements. For quality specifications dependent on between-subject variation, the lower estimates from European and American studies should be used. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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