Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study).
Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD). However, knowledge about how these affect the mortality of subjects with NAFLD is scarce. Therefore, we investigated the impact...
| Publicado en: | Scandinavian Journal of Clinical & Laboratory Investigation Vol. 80; no. 2; pp. 106 - 114 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142533102&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142533102 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00365513 BD5 jtl: Scandinavian Journal of Clinical & Laboratory Investigation issn: 00365513 maglogo: Y pubinfo: dt: Mar2020 vid: 80 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 142533102 142533102 NLM31851849 142533102 10.1080/00365513.2019.1700428 NLM31851849 142533102 ppf: 106 ppct: 8 formats: tig: atl: Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study). aug: au: Käräjämäki, Aki Juhani Hukkanen, Janne Kauma, Heikki Kesäniemi, Y. Antero Ukkola, Olavi affil: Department of Gastroenterology, Vaasa Central Hospital, Vaasa, Finland sug: subj: Nonalcoholic Fatty Liver Disease Membrane Proteins Polymorphism, Genetic Nonalcoholic Fatty Liver Disease Mortality Acyltransferases Lipase Middle Age Adult Disease Susceptibility Cardiovascular Diseases Mortality Finland Risk Factors Male Cardiovascular Diseases Nonalcoholic Fatty Liver Disease Complications Case Control Studies Female Human Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD). However, knowledge about how these affect the mortality of subjects with NAFLD is scarce. Therefore, we investigated the impact of MetS, PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 on overall and cardiovascular disease (CVD) specific mortality among subjects with or without NAFLD. NAFLD diagnosis was based on liver ultrasound at the baseline. After this and other comprehensive examinations, 958 middle-aged Finns, 249 with NAFLD, were followed for 21 years. The mortality data was gathered from the National Death Registry. After multiple adjustments, the NAFLD individuals with MetS had increased risk of overall mortality as compared to the NAFLD subjects without MetS [2.054 (1.011-4.173, p = .046)]. However, PNPLA3 rs738409 [1.049 (0.650-1.692, p = .844)], TM6SF2 rs58542926 [0.721 (0.369-1.411, p = .340)] or MBOAT7 rs641738 [0.885 (0.543-1.439, p = .621)] did not affect the overall mortality. MetS was also a marker of increased risk of CVD mortality (15% vs. 2%, p = .013) while genetic polymorphisms did not affect CVD mortality. In conclusion, MetS, but not the gene polymorphisms studied, predicts increased overall and CVD-specific mortality among NAFLD subjects. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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