Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight/obesity.
Summary: Background: The relationship of obesity with grey and white matter volumes has been examined in several studies, and the results are decidedly mixed. Objective: To investigate the associations of body mass index (BMI), fat mass index (FMI) and lean mass index (LMI) with total and regional g...
| Published in: | Pediatric Obesity Vol. 15; no. 5; pp. 1 - 11 |
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| Main Authors: | , , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
May2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142538560&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142538560 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20476302 ETV7 jtl: Pediatric Obesity issn: 20476302 maglogo: Y pubinfo: dt: May2020 vid: 15 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142538560 142538560 145815924 142538560 10.1111/ijpo.12604 142538560 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight/obesity. aug: au: Gracia‐Marco, Luis Esteban‐Cornejo, Irene Ubago‐Guisado, Esther Rodriguez‐Ayllon, Maria Mora‐Gonzalez, Jose Solis‐Urra, Patricio Cadenas‐Sanchez, Cristina Verdejo‐Roman, Juan Catena, Andres Erickson, Kirk I. Ortega, Francisco B. affil: PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain sug: subj: Pediatric Obesity Diagnosis White Matter Anatomy and Histology Gray Matter Anatomy and Histology Body Composition Evaluation Body Mass Index Human Cross Sectional Studies Male Magnetic Resonance Imaging Methods Absorptiometry, Photon Educational Status Sex Factors Multiple Regression Male ab: Summary: Background: The relationship of obesity with grey and white matter volumes has been examined in several studies, and the results are decidedly mixed. Objective: To investigate the associations of body mass index (BMI), fat mass index (FMI) and lean mass index (LMI) with total and regional grey and white matter volumes. Methods: This is a cross‐sectional study involving 100 children (60% boys) with overweight/obesity. T1‐weighted images were acquired using magnetic resonance imaging. Dual energy X‐ray absorptiometry was used to measure body composition. Separate hierarchical regression analyses were performed between predictor variables (BMI, FMI and LMI) and the total brain volumes including sex, years from peak height velocity and parental education as covariates. In addition, FMI was added as a covariate when LMI was the predictor and vice versa. Statistical analyses of imaging data were performed using three whole‐brain voxel‐wise multiple regression models and adjusted by the same covariates. Results: LMI was positively associated with white matter in numerous regions and to a lower extent, with grey matter regions. Further, the relationship between LMI, and grey and white matter regions was independent of FMI levels. Conclusions: LMI seems to be a positive predictor of regional white matter volumes in children with overweight/obesity. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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