Evaluation of a new combination: ceftriaxone-disodium edetate-sulbactam as a broad-spectrum option for multidrug-resistant bacterial infections.
Background: The presence of numerous antibiotic-resistance mechanisms in Gram-positive and Gram-negative bacteria is a global concern, which is further complicated by emergence of newer mechanisms in recent years. Few new compounds are in the production-pipeline that show potential for usage as anti...
| Publicado en: | New Zealand Journal of Medical Laboratory Science Vol. 74; no. 1; pp. 22 - 27 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
New Zealand Institute of Medical Laboratory Science
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142584174&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142584174 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11710195 H2G jtl: New Zealand Journal of Medical Laboratory Science issn: 11710195 maglogo: N pubinfo: dt: Apr2020 vid: 74 iid: 1 pid: 12822 pub: New Zealand Institute of Medical Laboratory Science artinfo: ui: 142584174 142584174 142584174 142584174 ppf: 22 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Evaluation of a new combination: ceftriaxone-disodium edetate-sulbactam as a broad-spectrum option for multidrug-resistant bacterial infections. aug: au: Shahid, Mohd. Ahmed, Shariq Iqbal, Zobair Sami, Hiba Singh, Anuradha affil: Department of Microbiology, Jawaharlal Nehru Medical College & Hospital, Aligarh Muslim University, Aligarh, UP, India sug: subj: Bacterial Infections Drug Therapy Ceftriaxone Therapeutic Use Edetic Acid Therapeutic Use Penicillins Therapeutic Use Drug Combinations Pharmacodynamics Drug Resistance, Multiple Drug Effects Microbial Culture and Sensitivity Tests Methods Human Prospective Studies In Vitro Studies Gram-Positive Bacteria Metabolism Gram-Negative Bacteria Metabolism beta-Lactamases Carbapenems Colistin Methicillin Vancomycin Metabolic Networks and Pathways Drug Effects Academic Medical Centers India Treatment Outcomes Evaluation ab: Background: The presence of numerous antibiotic-resistance mechanisms in Gram-positive and Gram-negative bacteria is a global concern, which is further complicated by emergence of newer mechanisms in recent years. Few new compounds are in the production-pipeline that show potential for usage as antimicrobial agents. Antibiotic adjuvant ceftriaxone-disodium edetate-sulbactam, available under tradename Elores™, showed potential in this study by demonstrating antimicrobial activity against various multidrugresistant bacteria. Methods: In this prospective in-vitro study, we tested the antimicrobial activity of Elores™ against a battery of clinical Gram-positive and Gram-negative bacterial isolates, including antibiotic-susceptible and antibiotic-resistant bacteria such as ESBL-producing Enterobacterales (ESBLPE), carbapenem-resistant Enterobacterales (CRE), Enterobacterales showing colistin-resistance (ECR), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VRE). Results: Elores™ showed excellent activity against the tested Gram-positive and Gram-negative bacterial species, including some highly resistant species such as ESBL-producers, CRE, species resistant to colistin, MRSA and VRE. Elores™ was non-inferior to tigecycline in VRE isolates and non-inferior to colistin in Escherichia coli, Citrobacter species, Pseudomonas aeruginosa and Acinetobacter baumannii. However, in Klebsiella species the activity of Elores™ was notably better than colistin. Conclusions: In addition to activity against ESBL-producers and CRE, the activity of Elores™ against colistin-resistant Enterobacterales, MRSA and VRE showed promise, indicating its use as a potential candidate for empirical therapy due to its high activity against multidrug-resistant Gram-positive and Gram-negative bacteria. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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