PET and SPECT imaging of the brain: a review on the current status of nuclear medicine in Japan.
Radiolabeled tracers allow visualization of not only perfusion, but receptors, function, and metabolism as well. Although spatial resolution is lower than that of computed tomography and magnetic resonance imaging, positron emission tomography (PET) and single photon emission computed tomography (SP...
| Publicado en: | Japanese Journal of Radiology Vol. 38; no. 4; pp. 343 - 358 |
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| Autor principal: | |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142683693&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142683693 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: Apr2020 vid: 38 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142683693 142683693 NLM32043236 142683693 10.1007/s11604-019-00901-8 NLM32043236 142683693 ppf: 343 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: PET and SPECT imaging of the brain: a review on the current status of nuclear medicine in Japan. aug: au: Kaneta, Tomohiro affil: Department of Advanced Molecular Imaging, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan sug: subj: Tomography, Emission-Computed, Single-Photon Methods Nuclear Medicine Methods Brain Cerebrovascular Circulation Tomography, Emission-Computed, Single-Photon Equipment and Supplies Elements Pharmacokinetics Brain Blood Supply Radioisotopes Zinc Pharmacokinetics Cadmium Pharmacokinetics Japan ab: Radiolabeled tracers allow visualization of not only perfusion, but receptors, function, and metabolism as well. Although spatial resolution is lower than that of computed tomography and magnetic resonance imaging, positron emission tomography (PET) and single photon emission computed tomography (SPECT) have great potential for target-specific imaging. In this review, we discuss several SPECT and PET tracers used in brain imaging, specifically focusing on tracers currently available, or developed, in Japan. Several important and sophisticated methods exist for analysis of brain PET and SPECT images. Two of them, quantitative cerebral blood flow measurement and voxel-based statistical analysis are discussed in this review. The former method, which employs acetazolamide loading, is useful for evaluation of the brain perfusion reserve for ischemic brain diseases. The latter is useful in diagnosing dementing diseases. Additionally, great strides have been made in the development of the technology used in the scanners. New SPECT systems based on cadmium-zinc-telluride, PET/MRI, and semiconductor PET/CT may provide higher spatial resolution with an acquisition time shorter than ever before. Such developments of both tracers and scanners can be integrated for unprecedented imagery of the brain, providing valuable insight into underlying causes of some fatal brain disorders. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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