Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia.
Background: An impairment of the peripheral nervous system has been suggested in fibromyalgia (FM). Noninvasive distal electrochemical skin conductance (ESC) has been studied little so far when combined with quantitative sensory testing (QST) in patients with FM. Methods: This study (clinicaltrials....
| Publicado en: | Pain Practice Vol. 20; no. 4; pp. 348 - 357 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142690378&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142690378 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307085 HYN jtl: Pain Practice issn: 15307085 maglogo: Y pubinfo: dt: Apr2020 vid: 20 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142690378 142690378 145863042 142690378 10.1111/papr.12857 142690378 ppf: 348 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia. aug: au: Pickering, Gisèle Achard, Alexanne Corriger, Alexandrine Sickout‐Arondo, Sophia Macian, Nicolas Leray, Vincent Lucchini, Camille Cardot, Jean‐Michel Pereira, Bruno affil: Neuro‐Dol Laboratory Inserm 1107, Clermont Auvergne University, Clermont‐Ferrand, France sug: subj: Electrochemical Techniques Methods Skin Physiology Evaluation Sweat Glands Physiopathology Sensation Evaluation Peripheral Nervous System Diseases Diagnosis Fibromyalgia Physiopathology Human Female Quality of Life Evaluation Sleep Evaluation Pain Threshold Evaluation Analgesia Type I Error Nerve Fibers Physiopathology Noninvasive Procedures Pain Management Female ab: Background: An impairment of the peripheral nervous system has been suggested in fibromyalgia (FM). Noninvasive distal electrochemical skin conductance (ESC) has been studied little so far when combined with quantitative sensory testing (QST) in patients with FM. Methods: This study (clinicaltrials.gov NCT03347669) included 50 female patients with FM and 50 matched healthy volunteers (HVs). ESC (measured in microsiemens [µS] with Sudoscan), as well as psychological, quality of life, sleep, and social characteristics, were assessed in both groups. In a subgroup of 24 patients with FM and 24 HVs, QST of cold and warm detection and pain thresholds and diffuse noxious inhibitory controls (DNICs) were explored. Statistical analysis was performed for a 2‐sided type I error at 5%. Results: Between patients with FM and HVs, ESC values differed (71.4 ± 11.2 µS vs. 74.4 ± 10.3 µS, respectively; P = 0.003), especially on the dominant hand (P = 0.03), where more patients with FM had ESC values < 66 µS than did HVs (P = 0.046). No difference was observed on feet. In patients with FM, all collected characteristics were impaired (P < 0.001), DNICs were less functional, detection thresholds occurred later, and pain thresholds occurred earlier. No correlation was observed between ESC and DNICs or with any parameter. Conclusion: This study shows that the sudomotor function is significantly impaired in patients with FM, especially on the dominant hand. This occurs in parallel with adjustments of detection and pain thresholds in the context of deficient spinal pain modulation. ESC values combined with QST values are relevant in the context of patients with FM and need to be explored further in this nociception‐autonomic system intertwining. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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