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A procedure for determining subject-specific pulse oxygen saturation response.

The oxyhemoglobin dissociation curve describes the relationship between the partial pressure of oxygen and the percent of hemoglobin saturated with oxygen and varies with chemical and physical factors that differ for every patient. If variability could be determined, patient-specific oxygen therapy...

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Published in:Medical & Biological Engineering & Computing Vol. 58; no. 4; pp. 753 - 762
Main Authors: Burk, Kyle M., Orr, Joseph A.
Format: Journal Article
Published: Springer Nature Apr2020
Online Access:View this record in EBSCOhost
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      dt: Apr2020
      vid: 58
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s11517-019-02105-8
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        atl: A procedure for determining subject-specific pulse oxygen saturation response.
      aug:
        au:
          Burk, Kyle M.
          Orr, Joseph A.
        affil: Department of Biomedical Engineering, University of Utah, 84132, Salt Lake City, UT, USA
      sug:
        subj:
          Oxygen Blood
          Oxygen Therapy Methods
          Oximetry Methods
          Hemoglobins Analysis
          Preoperative Care
          Models, Biological
      ab: The oxyhemoglobin dissociation curve describes the relationship between the partial pressure of oxygen and the percent of hemoglobin saturated with oxygen and varies with chemical and physical factors that differ for every patient. If variability could be determined, patient-specific oxygen therapy could be administered. We have developed a procedure for characterizing variations in the oxygen dissociation curve. The purpose of this study was to validate this procedure in surgical patients. The procedure uses an automated system to alter oxygen therapy during surgery, within safe operational levels, and fit to Hill's equation non-invasive measurements of end-tidal oxygen and peripheral pulse oxygen saturation. The best-fit parameters for the Hill equation, estimated by iterative least squares, provide an apparent dissociation curve, meaningful of the patient-specific pulse oximeter response. Thirty-nine patients participated in this study. Using patient-specific parameter values increases correlation when compared with standard values. The procedure improved the model fit of patient saturation values significantly in 19 patients. This paper has demonstrated a procedure for determining patient-specific pulse oximeter response. This procedure determined best-fit parameters resulting in a significantly improved fit when compared with standard values. These best-fit parameters increased the coefficient of determination R2 in all cases. Graphical Abstract This patient-specific procedure improves fit significantly compared to standard estimates.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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