Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy.
Previous neuroimaging studies have detected markers of neuroinflammation in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Magnetic Resonance Spectroscopy (MRS) is suitable for measuring brain metabolites linked to inflammation, but has only been applied to discrete regio...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 2; pp. 562 - 573 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142737972&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142737972 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2020 vid: 14 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142737972 142737972 NLM30617782 10.1007/s11682-018-0029-4 NLM30617782 142737972 ppf: 562 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy. aug: au: Mueller, Christina Lin, Joanne C. Sheriff, Sulaiman Maudsley, Andrew A. Younger, Jarred W. affil: Department of Psychology, The University of Alabama at Birmingham, 1720 2nd Ave S, 35294, Birmingham, AL, USA sug: subj: Fatigue Syndrome, Chronic Metabolism Immunity Physiology Fatigue Syndrome, Chronic Male Choline Analysis Fatigue Syndrome, Chronic Physiopathology Magnetic Resonance Imaging Methods Fatigue Metabolism Aspartic Acid Analysis Aspartic Acid Analogs and Derivatives Creatine Metabolism Brain Pathology Middle Age Adult Female Lactic Acid Analysis Neuroradiography Methods Inositol Analysis Magnetic Resonance Spectroscopy Methods Scales Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Previous neuroimaging studies have detected markers of neuroinflammation in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Magnetic Resonance Spectroscopy (MRS) is suitable for measuring brain metabolites linked to inflammation, but has only been applied to discrete regions of interest in ME/CFS. We extended the MRS analysis of ME/CFS by capturing multi-voxel information across the entire brain. Additionally, we tested whether MRS-derived brain temperature is elevated in ME/CFS patients. Fifteen women with ME/CFS and 15 age- and gender-matched healthy controls completed fatigue and mood symptom questionnaires and whole-brain echo-planar spectroscopic imaging (EPSI). Choline (CHO), myo-inositol (MI), lactate (LAC), and N-acetylaspartate (NAA) were quantified in 47 regions, expressed as ratios over creatine (CR), and compared between ME/CFS patients and controls using independent-samples t-tests. Brain temperature was similarly tested between groups. Significant between-group differences were detected in several regions, most notably elevated CHO/CR in the left anterior cingulate (p < 0.001). Metabolite ratios in seven regions were correlated with fatigue (p < 0.05). ME/CFS patients had increased temperature in the right insula, putamen, frontal cortex, thalamus, and the cerebellum (all p < 0.05), which was not attributable to increased body temperature or differences in cerebral perfusion. Brain temperature increases converged with elevated LAC/CR in the right insula, right thalamus, and cerebellum (all p < 0.05). We report metabolite and temperature abnormalities in ME/CFS patients in widely distributed regions. Our findings may indicate that ME/CFS involves neuroinflammation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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