Stroop-related cerebellar and temporal activation is correlated with negative affect and alcohol use disorder severity.
Impairment in cognitive control in alcohol use disorder (AUD) contributes to difficulty controlling alcohol use and, in many populations, difficulties with emotion regulation. However, the most reliable and robust marker of clinically-relevant deficits in cognitive control in AUD is unclear. Our aim...
| Published in: | Brain Imaging & Behavior Vol. 14; no. 2; pp. 586 - 599 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Apr2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142737977&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142737977 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2020 vid: 14 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142737977 142737977 NLM31115861 10.1007/s11682-019-00126-3 NLM31115861 142737977 ppf: 586 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Stroop-related cerebellar and temporal activation is correlated with negative affect and alcohol use disorder severity. aug: au: Wilcox, Claire E. Clifford, Joshua Ling, Josef Mayer, Andrew R. Bigelow, Rose Bogenschutz, Michael P. Tonigan, J. Scott affil: Mind Research Network, 1101 Yale Blvd. NE, 87106, Albuquerque, NM, USA sug: subj: Cognition Alcoholism Psychosocial Factors Alcoholism Physiopathology Middle Age Behavior Drug Effects Male Alcoholism Metabolism Brain Physiopathology Neuropsychological Tests Magnetic Resonance Imaging Methods Affect Drug Effects Cerebellum Physiopathology Adult Female Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Impairment in cognitive control in alcohol use disorder (AUD) contributes to difficulty controlling alcohol use and, in many populations, difficulties with emotion regulation. However, the most reliable and robust marker of clinically-relevant deficits in cognitive control in AUD is unclear. Our aims were to measure relationships between BOLD signal during a Stroop task and AUD severity and change in BOLD signal and change in drinking over three weeks. We also aimed to explore the relationships between BOLD signal and subjective negative affect. Thirty-three individuals with AUD underwent a multisensory Stroop task during functional magnetic resonance imaging (fMRI), as well as a battery of neuropsychological tests and self-report assessments of negative affect and AUD severity. Greater activation in temporal gyrus and cerebellum during incongruent trials compared to congruent trials was observed, and percent signal change (incongruent minus congruent) in both clusters was positively correlated with AUD severity and self-reported negative affect. Neuropsychological task performance and self-reported impulsivity were not highly correlated with AUD severity. Hierarchical regression analyses indicated that percent signal change (incongruent minus congruent) in cerebellum was independently associated with negative affect after controlling for recent and chronic drinking. In a subset of individuals (n = 23) reduction in cerebellar percent signal change (incongruent minus congruent) was correlated with increases in percent days abstinent over 3 weeks. BOLD activation during this Stroop task may therefore be an important objective marker of AUD severity and negative affect. The potential importance of the cerebellum in emotion regulation and AUD severity is highlighted. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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