Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects.
A healthy brain is essential for living a longer and fuller life. Detecting asymptomatic white matter hyperintensities (WMHs) may be clinically important in terms of treatment and prognostic evaluation. WMHs in brain may reflect brain aging. Androgenic alopecia (AGA) is associated with significant c...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 2; pp. 527 - 534 |
|---|---|
| Autor principal: | |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142737982&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142737982 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2020 vid: 14 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142737982 142737982 NLM31250269 10.1007/s11682-019-00147-y NLM31250269 142737982 ppf: 527 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. aug: au: Ata Korkmaz, Hatice Ayca affil: Department of Radiology, University of Health Science, Kanuni Research and Education Hospital, Trabzon, Turkey sug: subj: Brain Pathology Alopecia Pathology Alopecia Metabolism Magnetic Resonance Imaging Methods Aged Male Research Subjects Adult Aging Prognosis Risk Factors Middle Age Brain Metabolism Hamilton Rating Scale for Depression Impact of Events Scale Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male ab: A healthy brain is essential for living a longer and fuller life. Detecting asymptomatic white matter hyperintensities (WMHs) may be clinically important in terms of treatment and prognostic evaluation. WMHs in brain may reflect brain aging. Androgenic alopecia (AGA) is associated with significant cardiovascular risk factors that also have a negative impact on brain aging. The main purpose of present study was to know whether alopecia might provide predictive information of WMHs that may be considered as a surrogate marker of cerebral small vessel disease which is related to arteriolosclerosis and vascular risk factors. From January 2017 to March 2018, 256 cases were enrolled consecutively. Patients under 18 years old, older than 90 years old, known to be affected by neurodegenerative diseases, demyelinating disorders or stroke and/or a brain tumor, were excluded from the study. A 4-point cerebral white matter Magnetic Resonance Imaging (MRI) hyperintensities scoring system, the Fazekas scale, was used to evaluate brain aging. Presence of AGA was evaluated with inspection according to Hamilton-Norwood classification system (grade I to VII). Two hundred eleven (82%) of individuals had mild alopecia (grade I, II, III), 28 (11%) had moderate alopecia (grade IV, V) and 17 (7%) had severe alopecia (grade VI, VII). Frequency of abnormal WMHs was significantly higher in patients with AGA compared to the without AGA. Hypertension (HT) (95% confidence interval [CI]: 1.873-9.487, p < 0.001) and the AGA (95% CI: 2.989-12.916, p < 0.0001) were independent determinants of abnormal WMHs. AGA may be regarded as a surrogate marker of asymptomatic WMHs which is related to arteriolosclerosis and vascular risk factors that has a significant impact on people's life. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|