Age associated decline in the arcuate fasciculus and IQ.

The arcuate fasciculus (AF) has been implicated in its association with intelligence. Probabilistic tractography on diffusion tensor imaging (DTI) data provides isolation of white matter tracts between two distant cortical structures. In this study, we performed probabilistic tractography between We...

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Publicado en:Brain Imaging & Behavior Vol. 14; no. 2; pp. 362 - 368
Autores principales: Ikuta, Toshikazu, Gollnick, Hannah M., Rutledge, Anna N.
Formato: Journal Article
Publicado: Springer Nature Apr2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2020
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      pub: Springer Nature
      place: New York, New York
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        atl: Age associated decline in the arcuate fasciculus and IQ.
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          Ikuta, Toshikazu
          Gollnick, Hannah M.
          Rutledge, Anna N.
        affil: Department of Communication Sciences and Disorders, University of Mississippi, Oxford, MS, USA
      sug:
        subj:
          Brain Pathology
          Aging Physiology
          Adult
          Middle Age
          Frontal Lobe
          Aged
          Aged, 80 and Over
          Female
          Brain
          Parietal Lobe Pathology
          Frontal Lobe Pathology
          Neural Pathways Physiology
          Parietal Lobe
          Male
          Nervous System
          Magnetic Resonance Imaging Methods
          Neural Pathways
          Child
          Adolescence
          Dominance, Cerebral
          Intelligence
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Child: 6-12 years
          Adolescent: 13-18 years
          Female
          Male
      ab: The arcuate fasciculus (AF) has been implicated in its association with intelligence. Probabilistic tractography on diffusion tensor imaging (DTI) data provides isolation of white matter tracts between two distant cortical structures. In this study, we performed probabilistic tractography between Wernicke's and Broca's area in the left and right hemisphere, to examine the association of the arcuate fasciculus's integrity with age and intelligence, using DTI data from 488 individuals whose age ranges between 6 to 85 years. The left, but not right, AF showed significant decline with age. Both left and right AF showed significant association with the full-scale IQ measured by the Wechsler Abbreviated Intelligence Scale. Both fasciculi showed significant association with the subscale verbal IQ, but only the left showed performance IQ. This study demonstrates that the bilateral arcuate fasciculi are associated with IQ; left vs. right asymmetry is present in its aging and function.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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