Increased interregional functional connectivity of anterior insula is associated with improved smoking cessation outcome.
Damage to the insular cortex has been shown to disrupt smoking behavior. However, whether smoking cessation outcomes are associated with abnormal functions of insula and its subregions remains unclear. In this study, we investigated the relationship between insular functions (interregional functiona...
| Published in: | Brain Imaging & Behavior Vol. 14; no. 2; pp. 408 - 416 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Apr2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142737988&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142737988 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2020 vid: 14 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142737988 142737988 NLM31494823 10.1007/s11682-019-00197-2 NLM31494823 142737988 ppf: 408 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Increased interregional functional connectivity of anterior insula is associated with improved smoking cessation outcome. aug: au: Wang, Chao Shen, Zhujing Huang, Peiyu Qian, Wei Zhou, Cheng Li, Kaicheng Zeng, Qingze Luo, Xiao Gu, Quanquan Yu, Hualiang Yang, Yihong Zhang, Minming affil: Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China sug: subj: Cerebral Cortex Physiopathology Substance Use Disorders Physiopathology Smoking Physiopathology Magnetic Resonance Imaging Methods Brain Physiopathology China Smoking Cessation Neural Pathways Physiopathology Parietal Lobe Physiopathology Brain Mapping Methods Asians Frontal Lobe Physiopathology Middle Age Male Adult Clinical Assessment Tools Middle Aged: 45-64 years Adult: 19-44 years Male ab: Damage to the insular cortex has been shown to disrupt smoking behavior. However, whether smoking cessation outcomes are associated with abnormal functions of insula and its subregions remains unclear. In this study, we investigated the relationship between insular functions (interregional functional connectivity and regional activity) and treatment outcomes of cigarette smoking. Thirty treatment-seeking smokers were recruited into the treatment study and underwent magnetic resonance imaging (MRI) scans immediately before and after the treatment. Sixteen participants remained abstinent from smoking (quitters), while 14 relapsed to smoking (relapers). Changes in resting-state functional connectivity and fractional amplitude of low frequency fluctuation (fALFF) across groups and visits were assessed using repeated measures ANCOVA. Significant interaction effects were detected: 1) between the left anterior insula and left precuneus; and 2) between the right anterior insula and left precuneus and medial frontal gyrus. Post-hoc region-of-interest analyses in brain areas showing interaction effects indicated significantly increased functional connectivity after treatment compared with before treatment in quitters but opposite longitudinal changes in relapsers. However, no significant effects in fALFF were observed. These novel findings suggest that increased interregional functional connectivity of the anterior insula is associated with improved smoking cessation outcome: individuals with increased functional connectivity of the anterior insula during the treatment would more likely quit smoking successfully. These insular circuits may serve as therapeutic targets for more efficacious treatment of nicotine addiction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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