The impact of endurance training and table soccer on brain metabolites in schizophrenia.
Higher glutamate and glutamine (together: Glx) and lower N-acetyl-aspartate (NAA) levels were reported in schizophrenia. Endurance training normalizes NAA in the hippocampus, but its effects on other metabolites in the brain and the relationship of metabolites to clinical symptoms remain unknown. Fo...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 2; pp. 515 - 527 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142737989&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142737989 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2020 vid: 14 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142737989 142737989 NLM31686308 10.1007/s11682-019-00198-1 NLM31686308 142737989 ppf: 515 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The impact of endurance training and table soccer on brain metabolites in schizophrenia. aug: au: Rauchmann, Boris-Stephan Ghaseminejad, Farhad Keeser, Daniel Keller-Varady, Katriona Schneider-Axmann, Thomas Takahashi, Shun Karali, Temmuz Helms, Gunther Dechent, Peter Maurus, Isabel Hasan, Alkomiet Wobrock, Thomas Ertl-Wagner, Birgit Schmitt, Andrea Malchow, Berend Falkai, Peter affil: Department of Radiology, University Hospital, LMU Munich, Munich, Germany sug: subj: Cognition Schizophrenia Metabolism Hippocampus Metabolism Brain Metabolism Male Thalamus Pathology Magnetic Resonance Spectroscopy Methods Adult Frontal Lobe Pathology Glutamic Acid Metabolism Neurons Metabolism Brain Creatine Metabolism Hippocampus Pathology Inpatients Hippocampus Glutamine Metabolism Female Aspartic Acid Metabolism Brain Pathology Scales Adult: 19-44 years Male Female ab: Higher glutamate and glutamine (together: Glx) and lower N-acetyl-aspartate (NAA) levels were reported in schizophrenia. Endurance training normalizes NAA in the hippocampus, but its effects on other metabolites in the brain and the relationship of metabolites to clinical symptoms remain unknown. For 12 weeks, 20 schizophrenia inpatients (14 men, 6 women) and 23 healthy controls (16 men, 7 women) performed endurance training and a control group of 21 schizophrenia inpatients (15 men, 6 women) played table soccer. A computer-assisted cognitive performance training program was introduced after 6 weeks. We assessed cognitive performance, psychopathological symptoms, and everyday functioning at baseline and after 6 and 12 weeks and performed single voxel magnetic resonance spectroscopy of the hippocampus, left dorsolateral prefrontal cortex (DLPFC), and thalamus. We quantified NAA, Glx, total creatine (tCr), calculated NAA/tCr and Glx/tCr and correlated these ratios with physical fitness, clinical and neurocognitive scores, and everyday functioning. At baseline, in both schizophrenia groups NAA/tCr was lower in the left DLPFC and left hippocampus and Glx/tCr was lower in the hippocampus than in the healthy controls. After 6 weeks, NAA/tCr increased in the left DLPFC in both schizophrenia groups. Brain metabolites did not change significantly in the hippocampus or thalamus, but the correlation between NAA/tCr and Glx/tCr normalized in the left DLPFC. Global Assessment of Functioning improvements correlated with NAA/tCr changes in the left DLPFC. In our study, endurance training and table soccer induced normalization of brain metabolite ratios in the brain circuitry associated with neuronal and synaptic elements, including metabolites of the glutamatergic system. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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