Cone-beam breast CT features associated with HER2/neu overexpression in patients with primary breast cancer.
Objectives: To identify the relationship between human epidermal growth factor receptor 2 (HER2) status and cone-beam breast CT (CBBCT) characteristics in surgically resected breast cancer.Methods: Preoperative CBBCT of patients with BI-RADS 4 or 5 lesions identified on mammography or ultrasound and...
| Publicado en: | European Radiology Vol. 30; no. 5; pp. 2731 - 2740 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142738702&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142738702 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2020 vid: 30 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142738702 142738702 NLM31900700 10.1007/s00330-019-06587-w NLM31900700 142738702 ppf: 2731 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cone-beam breast CT features associated with HER2/neu overexpression in patients with primary breast cancer. aug: au: Zhu, Yueqiang Zhang, Yuwei Ma, Yue Li, Haijie Liu, Aidi Han, Peng Yin, Lu Lv, Nan Li, Zhijun Lu, Hong Liu, Peifang Ye, Zhaoxiang affil: Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Huan-Hu-Xi Road, Ti-Yuan-Bei, Hexi District, 300060, Tianjin, China sug: subj: Mammography Methods Receptors, Cell Surface Tomography, X-Ray Computed Methods Breast Neoplasms Diagnosis Aged Female ROC Curve Middle Age Reproducibility of Results Adult Breast Neoplasms Metabolism Biopsy Retrospective Design Barthel Index Psychological Tests Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female ab: Objectives: To identify the relationship between human epidermal growth factor receptor 2 (HER2) status and cone-beam breast CT (CBBCT) characteristics in surgically resected breast cancer.Methods: Preoperative CBBCT of patients with BI-RADS 4 or 5 lesions identified on mammography or ultrasound and dense or very dense breast tissue were retrospectively evaluated in 181 surgically resected breast cancer (triple-negative excluded) between May 2012 and November 2014. A set of CBBCT descriptors was semiquantitatively assessed by consensus double reading. Reader reproducibility was analyzed. Multivariable logistic regression analysis using backward elimination (BEA) with the Wald criterion was performed to identify independent predictive factors of harboring HER2/neu. Principle component analysis (PCA) was used to determine characteristics that might differentiate HER2 status. Receiver operating characteristic (ROC) curve analyses were conducted to determine the predictive capability.Results: HER2 positive was found in 101 (55.8%) of 181 patients. Inter-observer agreement was high for characteristics' assessment. Based on BEA, pathologic grade, maximum dimension, lobulation, ΔCT, and calcification morphology were confirmed as independent predictive factors of HER2/neu overexpression. PCA showed that calcification- and border-related characteristics were the most important for differentiation. ROC curve analyses showed that CBBCT features (AUC = 0.853) were superior to clinicopathologic features (AUC = 0.613, p < 0.001) and comparable with combination (AUC = 0.856, p = 0.866).Conclusions: CBBCT features could be used to prognosticate HER2 status independently, which are potentially complementary to histopathologic result and helpful in guiding biopsy.Key Points: • Dmax, lobulation, ΔCT, and calcification morphology are independent predictors of HER2 status. • CBBCT features are superior to clinicopathologic features in HER2+/- discrimination. • CBBCT features are comparable with combination with clinicopathologic features in HER2+/- discrimination. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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