Potential value of CT radiomics in the distinction of intestinal-type gastric adenocarcinomas.
Objective: The purpose of the study was to investigate the role of CT radiomics for the preoperative distinction of intestinal-type gastric adenocarcinomas.Materials and Methods: A total of 187 consecutive patients with preoperative contrast CT examination and pathologically proven gastric adenocarc...
| Publicado en: | European Radiology Vol. 30; no. 5; pp. 2934 - 2945 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142738729&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142738729 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2020 vid: 30 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142738729 142738729 NLM32020404 142738729 10.1007/s00330-019-06629-3 NLM32020404 142738729 ppf: 2934 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Potential value of CT radiomics in the distinction of intestinal-type gastric adenocarcinomas. aug: au: Wang, Yue Liu, Wei Yu, Yang Han, Wei Liu, Jing-Juan Xue, Hua-Dan Lei, Jing Jin, Zheng-Yu Yu, Jian-Chun affil: Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, 100730, Bejing, People's Republic of China sug: subj: Adenocarcinoma Tomography, X-Ray Computed Methods Stomach Neoplasms Models, Statistical Adult Aged Male Preoperative Period Pharmacokinetics Retrospective Design Algorithms ROC Curve Young Adult Aged, 80 and Over Software Female Middle Age Human Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Male Female ab: Objective: The purpose of the study was to investigate the role of CT radiomics for the preoperative distinction of intestinal-type gastric adenocarcinomas.Materials and Methods: A total of 187 consecutive patients with preoperative contrast CT examination and pathologically proven gastric adenocarcinoma were retrospectively collected. Patients were divided into a training set (n = 150) and a test set (n = 37). Arterial phase (AP), portal phase (PP), and delay phase (DP) images were retrieved for analysis. A dedicated postprocessing software was used to segment the lesions and extract radiomics features. Random forest (RF) algorithm was applied to construct the classifier models. A nomogram was developed by incorporating multiphase radiomics scores. Receiver operating characteristic (ROC) curves were used to evaluate the performance of the radiomics model and nomogram in both sets.Results: The radiomics model showed a favorable capability in the distinction of intestinal-type gastric adenocarcinomas. The areas under curves (AUCs) of the AP, PP, and DP radiomics models were 0.754 (95% CI: 0.676, 0.820), 0.815 (95% CI: 0.744, 0.874), and 0.764 (95% CI: 0.688, 0.829) in the training set, respectively, which were confirmed in the test set with AUCs of 0.742 (95% CI: 0.572, 0.872), 0.775 (95% CI: 0.608, 0.895), and 0.857 (95% CI: 0.703, 0.950), respectively. The nomogram yielded excellent performance for distinguishing intestinal-type adenocarcinomas in both sets, with AUCs of 0.928 (95%: 0.875, 0.964) and 0.904 (95% CI: 0.761, 0.976).Conclusions: The multiphase CT radiomics nomogram holds promise for the individual preoperative discrimination of intestinal-type gastric adenocarcinoma.Key Points: • CT radiomics has a potential role in the distinction of intestinal-type gastric adenocarcinomas. • Single-phase enhanced CT-based radiomics showed favorable capability in distinguishing intestinal-type tumors. • The nomogram which incorporates the multiphase radiomics scores could facilitate the individual prediction of intestinal-type lesions. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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