Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: A meta-analysis of randomized controlled clinical trials.
Objective: This meta-analysis was performed to systematically evaluate the efficacy of hyaluronidase combined with corticosteroids compared with other drugs in improving maximum mouth opening and alleviating the burning sensation in patients with oral submucous fibrosis (OSF).Methods: PubMed, Embase...
| Published in: | Journal of Oral Pathology & Medicine Vol. 49; no. 4; pp. 311 - 320 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Apr2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142767674&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142767674 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09042512 8E8 jtl: Journal of Oral Pathology & Medicine issn: 09042512 maglogo: Y pubinfo: dt: Apr2020 vid: 49 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142767674 142767674 145771676 NLM32145110 142767674 10.1111/jop.13009 NLM32145110 142767674 ppf: 311 ppct: 9 formats: tig: atl: Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: A meta-analysis of randomized controlled clinical trials. aug: au: Guo, Jincai Xie, Hui Mao, Shun Liang, Mining Wu, Hao affil: Changsha Stomatological Hospital, Changsha, China sug: subj: Adrenal Cortex Hormones Therapeutic Use Mouth Diseases Drug Therapy Hyaluronidase Therapeutic Use Human Clinical Trials Meta Analysis Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source ab: Objective: This meta-analysis was performed to systematically evaluate the efficacy of hyaluronidase combined with corticosteroids compared with other drugs in improving maximum mouth opening and alleviating the burning sensation in patients with oral submucous fibrosis (OSF).Methods: PubMed, Embase, Web of Science and the Cochrane Library were searched. RevMan 5.3 software was used for the meta-analysis.Results: Six studies involving 244 patients with OSF were analysed. No significant difference in improvement of maximum mouth opening was found between the hyaluronidase and control groups (lycopene, pentoxifylline, aloe vera, dexamethasone, Turmix [curcumin + piperine] and isoxsuprine) at 1 month (mean difference [MD]: 0.32, 95% confidence interval [CI]: -0.92-1.56, P = .61, I2 = 57%), 2 months (MD: 0.49, 95% CI: -0.14-1.12, P = .12, I2 = 41%) or 3 months (MD: 0.40, 95% CI: -1.08-1.87, P = .60, I2 = 92%). Additionally, no statistically significant difference was found in alleviation of the burning sensation between the two groups at 1 month (MD: 0.54, 95% CI: -0.62-1.71, P = .36, I2 = 0%), 2 months (MD: 0.53, 95% CI: -0.85-1.91, P = .45, I2 = 0%) or 3 months (MD: 0.64, 95% CI: -1.07 to 2.35, P = .46, I2 = 0%).Conclusions: According to this meta-analysis, weak evidence indicates that hyaluronidase combined with corticosteroids has no additional clinical benefit over control drugs (lycopene, pentoxifylline, aloe vera, dexamethasone, Turmix and isoxsuprine) in improving maximum mouth opening and alleviating the burning sensation in patients with OSF. Therefore, more high-quality, multi-centre randomized controlled trials with larger samples are needed to further assess the efficacy of hyaluronidase combined with corticosteroids in the treatment of OSF. pubtype: Academic Journal doctype: meta analysis research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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