Debugging Adaptive Deep Brain Stimulation for Parkinson's Disease.
Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease. In adaptive DBS, stimulation is titrated according to feedback about clinical state and underlying pathophysiology. This contrasts with conventional stimulation, which is fixed and continuous. In acute tria...
| Publicado en: | Movement Disorders Vol. 35; no. 4; pp. 555 - 562 |
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| Autores principales: | , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142770491&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142770491 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08853185 O71 jtl: Movement Disorders issn: 08853185 maglogo: Y pubinfo: dt: Apr2020 vid: 35 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142770491 142770491 145814449 NLM32039501 142770491 10.1002/mds.27996 NLM32039501 142770491 ppf: 555 ppct: 7 formats: tig: atl: Debugging Adaptive Deep Brain Stimulation for Parkinson's Disease. aug: au: Little, Simon Brown, Peter affil: Department of Movement Disorders and Neuromodulation, University of California San Francisco, San Francisco California,, USA sug: subj: Parkinson Disease Therapy Deep Brain Stimulation Human Treatment Outcomes Comparative Studies Multicenter Studies Evaluation Research Validation Studies Funding Source ab: Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease. In adaptive DBS, stimulation is titrated according to feedback about clinical state and underlying pathophysiology. This contrasts with conventional stimulation, which is fixed and continuous. In acute trials, adaptive stimulation matches the efficacy of conventional stimulation while delivering about half the electrical energy. The latter means potentially fewer side-effects. The next step is to determine the long-term efficacy, efficiency, and side-effect profile of adaptive stimulation, and chronic trials are currently being considered by the medical devices industry. However, there are several different approaches to adaptive DBS, and several possible limitations have been highlighted. Here we review the findings to date to ascertain how and who to stimulate in chronic trials designed to establish the long-term utility of adaptive DBS. © 2020 International Parkinson and Movement Disorder Society. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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