Acute kidney injury in critically ill children and 5-year hypertension.
Background: To develop a pediatric-specific hypertension algorithm using administrative data and use it to evaluate the association between acute kidney injury (AKI) in the intensive care unit (ICU) and hypertension diagnosis 5 years post-discharge. Methods: Two-center retrospective cohort study of...
| Publicado en: | Pediatric Nephrology Vol. 35; no. 6; pp. 1097 - 1108 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142908708&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142908708 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Jun2020 vid: 35 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142908708 142908708 142908708 10.1007/s00467-020-04488-5 142908708 ppf: 1097 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Acute kidney injury in critically ill children and 5-year hypertension. aug: au: Hessey, Erin Perreault, Sylvie Roy, Louise Dorais, Marc Samuel, Susan Phan, Véronique Lafrance, Jean-Philippe Zappitelli, Michael affil: Department of Pediatrics, Division of Nephrology, Montreal Children's Hospital, McGill University Health Centre, Montreal, Québec, Canada sug: subj: Critically Ill Patients In Infancy and Childhood Kidney Failure, Acute Hypertension Diagnosis Algorithms Intensive Care Units Patient Discharge Human Retrospective Design Prospective Studies Canada Prevalence Infant Child, Preschool Child Male Female Descriptive Statistics Confidence Intervals Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Background: To develop a pediatric-specific hypertension algorithm using administrative data and use it to evaluate the association between acute kidney injury (AKI) in the intensive care unit (ICU) and hypertension diagnosis 5 years post-discharge. Methods: Two-center retrospective cohort study of children (≤ 18 years old) admitted to the pediatric ICU in Montreal, Canada, between 2003 and 2005 and followed until 2010. Patients with a valid healthcare number and without end-stage renal disease were included. Patients who could not be merged with the provincial database, did not survive admission, underwent cardiac surgery, had pre-existing renal disease associated with hypertension or a prior diagnosis of hypertension were excluded. AKI defined using the Kidney Disease: Improving Global Outcomes (KDIGO) definition. Using diagnostic codes and medications from administrative data, novel pediatric-specific hypertension definitions were designed. Both the evaluation of the prevalence of hypertension diagnosis and the association between AKI and hypertension occurred. Results: Nineteen hundred and seventy eight patients were included (median age at admission [interquartile range] 4.3 years [1.1–11.8], 44% female, 325 (16.4%) developed AKI). Of these patients, 130 (7%) had a hypertension diagnosis 5 years after discharge. Patients with AKI had a higher prevalence of hypertension diagnosis [non-AKI: 84/1653 (5.1%) vs. AKI: 46/325 (14.2%), p <.001]. Children with AKI had a higher adjusted risk of hypertension diagnosis (hazard ratio [95% confidence interval] 2.19 [1.47–3.26]). Conclusions: Children admitted to the ICU have a high prevalence of hypertension post-discharge and children with AKI have over two times higher risk of hypertension compared to those with no AKI. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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