A combined DTI and resting state functional MRI study in patients with postherpetic neuralgia.
Purpose: To explore the brain microstructural and functional changes in patients with postherpetic neuralgia (PHN).Materials and Methods: 12 PHN patients and 12 healthy volunteers were enrolled. Diffusion tensor imaging (DTI) and resting-state functional MRI (rfMRI) sequences were scanned by a 3T MR...
| Published in: | Japanese Journal of Radiology Vol. 38; no. 5; pp. 440 - 451 |
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| Main Authors: | , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
May2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142926106&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142926106 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: May2020 vid: 38 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 142926106 142926106 NLM32067145 142926106 10.1007/s11604-020-00926-4 NLM32067145 142926106 ppf: 440 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A combined DTI and resting state functional MRI study in patients with postherpetic neuralgia. aug: au: Dai, Hui Jiang, Chengcheng Wu, Guanzuan Huang, Renjun Jin, Xiaohong Zhang, Zhongshuai Wang, Lina Li, Yonggang affil: Department of Radiology, First Affiliated Hospital of Soochow University, Shizi Street 188#, 215000, Suzhou, China sug: subj: Neuralgia, Postherpetic Brain Magnetic Resonance Imaging Methods Neuralgia, Postherpetic Physiopathology Brain Mapping Methods Aged Brain Physiopathology Middle Age Adult Female Male Human Funding Source Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Purpose: To explore the brain microstructural and functional changes in patients with postherpetic neuralgia (PHN).Materials and Methods: 12 PHN patients and 12 healthy volunteers were enrolled. Diffusion tensor imaging (DTI) and resting-state functional MRI (rfMRI) sequences were scanned by a 3T MR scanner. Fractional anisotropy (FA) and mean diffusivity (MD) t-maps were obtained following DTI data processing. The amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were obtained following rfMRI data processing. A two sample t-test was performed to compare the FA, MD, ALFF and fALFF differences between the PHN patients and healthy controls.Results: No significant differences were noted with regard to the parameters gender, age and education years between the two groups. FA, MD, ALFF and/or fALFF indicated significant alterations in specific pain or pain-related brain regions, such as brainstem, cerebellum, parietal lobe, precuneus, frontal lobe, temporal lobe, postcentral and precentral gyrus, corpus callosum, cingulate gyrus, putamen and insula.Conclusion: Multi-local alterations of spontaneous brain activity could form a network related to chronic pain, sensory discrimination, emotion and cognition, suggesting complicated central mechanisms of PHN. The combined-action of brain microstructure and function may play a critical role in comprehension of neurological mechanisms of PHN-induced pain. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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