Diagnostic value of myocardial strain using two‐dimensional speckle‐tracking echocardiography in acute cardiac allograft rejection: A systematic review and meta‐analysis.

Background: Two‐dimensional speckle‐tracking echocardiography (2D STE) has been demonstrated to have certain diagnostic utility in heart transplantation (HTX) patients with acute cardiac allograft rejection (ACAR). The aim of the systematic review and meta‐analysis was to evaluate the diagnostic val...

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Publicado en:Echocardiography Vol. 37; no. 4; pp. 561 - 570
Autores principales: Zhu, Shuangshuang, Li, Meng, Tian, Fangyan, Wang, Shuyuan, Li, Yuman, Yin, Ping, Zhang, Li, Xie, Mingxing
Formato: meta analysis research systematic review tables/charts Journal Article
Publicado: Wiley-Blackwell Apr2020
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Wiley-Blackwell
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        10.1111/echo.14637
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        atl: Diagnostic value of myocardial strain using two‐dimensional speckle‐tracking echocardiography in acute cardiac allograft rejection: A systematic review and meta‐analysis.
      aug:
        au:
          Zhu, Shuangshuang
          Li, Meng
          Tian, Fangyan
          Wang, Shuyuan
          Li, Yuman
          Yin, Ping
          Zhang, Li
          Xie, Mingxing
        affil: Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      sug:
        subj:
          Heart Transplantation
          Allografts
          Graft Rejection Evaluation
          Myocardium Ultrasonography
          Echocardiography Methods
          Sensitivity and Specificity
          Human
          Systematic Review
          Meta Analysis
          Ventricular Function, Left
          Endocardium Ultrasonography
          Biopsy Methods
          Confidence Intervals
      ab: Background: Two‐dimensional speckle‐tracking echocardiography (2D STE) has been demonstrated to have certain diagnostic utility in heart transplantation (HTX) patients with acute cardiac allograft rejection (ACAR). The aim of the systematic review and meta‐analysis was to evaluate the diagnostic value of common strain parameters for ACAR in HTX patients. Methods: After conducting a database search, we selected studies evaluating left ventricular global longitudinal strain (GLS), circumferential strain (CS), radial strain (RS), and free wall right ventricular longitudinal strain (RV FW) in rejection group vs rejection‐free group. Results: After reviewing 886 publications, seven studies were finally included in the meta‐analysis, representing the data of 1173 pairs of endomyocardial biopsy and echocardiographic examination. Heart transplantation patients with rejection had significantly lower GLS than rejection‐free subjects (weighted mean difference −2.32 (95% CI, −3.41 to −1.23; P <.001). Heart transplantation patients with rejection had significantly lower CS than rejection‐free subjects (weighted mean difference −2.49 (95% CI, −4.05 to −0.91; P =.0019). In addition, HTX patients with rejection also had significantly lower RV FW (weighted mean difference −4.90 (95% CI, −6.15 to −3.65; P <.001). Conclusions: The meta‐analysis and systematic review demonstrate that myocardial strain parameters derived from 2D STE may be useful in detecting ACAR in HTX patients. The present results provide encouraging evidence to consider the routine use of GLS, CS, and RV FW as markers of graft function involvement during ACAR.
      pubtype: Academic Journal
      doctype:
        meta analysis
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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