The Hemodynamic Effect of Enhanced External Counterpulsation Treatment on Atherosclerotic Plaque in the Carotid Artery: A Framework of Patient-Specific Computational Fluid Dynamics Analysis.
Long-term enhanced external counterpulsation (EECP) therapy has been recommended for antiatherogenesis in recent clinical observations and trials. However, the precise mechanism underlying the benefits has not been fully clarified. To quantify the effect of EECP intervention on arterial hemodynamic...
| Publicado en: | Cardiology Research & Practice pp. 1 - 13 |
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| Autores principales: | , , , , , , , , , |
| Formato: | algorithm diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/30/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=142974401&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 142974401 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20908016 B6CF jtl: Cardiology Research & Practice issn: 20908016 maglogo: N pubinfo: dt: 4/30/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 142974401 142974401 142974401 10.1155/2020/5903790 142974401 ppf: 1 ppct: 12 formats: tig: atl: The Hemodynamic Effect of Enhanced External Counterpulsation Treatment on Atherosclerotic Plaque in the Carotid Artery: A Framework of Patient-Specific Computational Fluid Dynamics Analysis. aug: au: Du, Jianhang Wu, Guangyao Wu, Bokai Liu, Chang Mai, Zhouming Liu, Yumeng Wang, Yawei Zhang, Pandeng Wu, Guifu Liu, Jia affil: Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518033, China sug: subj: Carotid Artery Diseases Surgery Atherosclerosis Surgery Hemodynamics Evaluation Counterpulsation Human Conceptual Framework Carotid Arteries Physiology Magnetic Resonance Angiography Models, Structural Algorithms Computer Simulation Carotid Arteries Ultrasonography Carotid Arteries Anatomy and Histology Shear Image Processing, Computer Assisted ab: Long-term enhanced external counterpulsation (EECP) therapy has been recommended for antiatherogenesis in recent clinical observations and trials. However, the precise mechanism underlying the benefits has not been fully clarified. To quantify the effect of EECP intervention on arterial hemodynamic environment, a framework of numerical assessment was introduced using a parallel computing algorithm. A 3D endothelial surface of the carotid artery with mild atherosclerotic plaque was constructed from images of magnetic resonance angiography (MRA). Physiologic boundary conditions were derived from images of the ultrasound flow velocity spectrum measured at the common carotid artery and before and during EECP intervention. Hemodynamic factors relating to wall shear stress (WSS) and its spatial and temporal fluctuations were calculated and analyzed, which included AWSS, OSI, and AWSSG. Measuring and computational results showed that diastole blood pressure, perfusion, and WSS level in carotid bifurcation were significantly increased during EECP intervention. Mean AWSS level throughout the model increased by 16.9%, while OSI level did not show a significant change during EECP. We thus suggested that long-term EECP treatment might inhibit the initiation and development of atherosclerotic plaque via improving the hemodynamic environment in the carotid artery. Meanwhile, EECP performance induced a 19.6% increase in AWSSG level, and whether it would influence the endothelial functions may need a further study. Moreover, the numerical method proposed in this study was expected to be useful for the instant assessment of clinical application of EECP. pubtype: Academic Journal doctype: algorithm diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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