Machine Learning Classification Algorithms to Predict aGvHD following Allo-HSCT: A Systematic Review.

Background:  The acute graft-versus-host disease (aGvHD) is the most important cause of mortality in patients receiving allogeneic hematopoietic stem cell transplantation. Given that it occurs at the stage of severe tissue damage, its diagnosis is late. With the advancement of machine learning (ML),...

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Publicado en:Methods of Information in Medicine Vol. 58; no. 6; pp. 205 - 213
Autores principales: Salehnasab, Cirruse, Hajifathali, Abbas, Asadi, Farkhondeh, Roshandel, Elham, Kazemi, Alireza, Roshanpoor, Arash
Formato: Journal Article
Publicado: Thieme Medical Publishing Inc. 2019
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2019
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      pub: Thieme Medical Publishing Inc.
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        atl: Machine Learning Classification Algorithms to Predict aGvHD following Allo-HSCT: A Systematic Review.
      aug:
        au:
          Salehnasab, Cirruse
          Hajifathali, Abbas
          Asadi, Farkhondeh
          Roshandel, Elham
          Kazemi, Alireza
          Roshanpoor, Arash
        affil: Department of Health Information Technology and Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
      sug:
        subj:
          Hematopoietic Stem Cell Transplantation Adverse Effects
          Graft Versus Host Disease Etiology
          Graft Versus Host Disease Diagnosis
          Algorithms
          Allografts
          Information Retrieval
          Arthritis Impact Measurement Scales
          Scales
      ab: Background:  The acute graft-versus-host disease (aGvHD) is the most important cause of mortality in patients receiving allogeneic hematopoietic stem cell transplantation. Given that it occurs at the stage of severe tissue damage, its diagnosis is late. With the advancement of machine learning (ML), promising real-time models to predict aGvHD have emerged.Objective:  This article aims to synthesize the literature on ML classification algorithms for predicting aGvHD, highlighting algorithms and important predictor variables used.Methods:  A systemic review of ML classification algorithms used to predict aGvHD was performed using a search of the PubMed, Embase, Web of Science, Scopus, Springer, and IEEE Xplore databases undertaken up to April 2019 based on Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statements. The studies with a focus on using the ML classification algorithms in the process of predicting of aGvHD were considered.Results:  After applying the inclusion and exclusion criteria, 14 studies were selected for evaluation. The results of the current analysis showed that the algorithms used were Artificial Neural Network (79%), Support Vector Machine (50%), Naive Bayes (43%), k-Nearest Neighbors (29%), Regression (29%), and Decision Trees (14%), respectively. Also, many predictor variables have been used in these studies so that we have divided them into more abstract categories, including biomarkers, demographics, infections, clinical, genes, transplants, drugs, and other variables.Conclusion:  Each of these ML algorithms has a particular characteristic and different proposed predictors. Therefore, it seems these ML algorithms have a high potential for predicting aGvHD if the process of modeling is performed correctly.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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