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Adverse reactions to meglumine antimoniate in Brazilian inpatients with visceral leishmaniases: A case series.

What is known and objectives: Adverse drug reactions (ADR) related to the treatment of visceral leishmaniasis (VL) can cause severe clinical complications. We report a case series of ADR in hospitalized VL patients on meglumine antimoniate (MA). Case description: Seven cases of patients taking MA ha...

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Publicado en:Journal of Clinical Pharmacy & Therapeutics Vol. 45; no. 3; pp. 573 - 577
Autores principales: Serbate Borges Portela, Áquila, Margotto Bertollo, Caryne, Silva Praxedes, Marcus Fernando, Silva Brasileiro, Sandro Aurélio, Moreira Reis, Adriano Max, Parreiras Martins, Maria Auxiliadora
Formato: research tables/charts Journal Article
Publicado: Wiley-Blackwell Jun2020
Acceso en línea:Ver este registro en EBSCOhost
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      issn: 02694727
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      dt: Jun2020
      vid: 45
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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      tig:
        atl: Adverse reactions to meglumine antimoniate in Brazilian inpatients with visceral leishmaniases: A case series.
      aug:
        au:
          Serbate Borges Portela, Áquila
          Margotto Bertollo, Caryne
          Silva Praxedes, Marcus Fernando
          Silva Brasileiro, Sandro Aurélio
          Moreira Reis, Adriano Max
          Parreiras Martins, Maria Auxiliadora
        affil: Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Brazil
      sug:
        subj:
          Sorbitol Adverse Effects
          Leishmaniasis, Visceral Drug Therapy
          Hospitalization Brazil
          Human
          Case Studies
          Inpatients
          Brazil
          Adolescence
          Adult
          Middle Age
          Male
          Female
          Descriptive Statistics
          Dermatitis Medicamentosa
          Hepatotoxicity
          Cardiotoxicity
          Pancreatitis
          Nephrotoxicity
          Aminotransferases Blood
          Amphotericin B Therapeutic Use
          Age Factors
          Electrocardiography
          Patient Safety
          Pharmacovigilance
          Early Intervention
          Adolescent: 13-18 years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: What is known and objectives: Adverse drug reactions (ADR) related to the treatment of visceral leishmaniasis (VL) can cause severe clinical complications. We report a case series of ADR in hospitalized VL patients on meglumine antimoniate (MA). Case description: Seven cases of patients taking MA had at least one objective evidence for suspected ADR, including electrocardiographic, laboratory or clinical alteration. What is new and conclusion: Meglumine antimoniate is highly toxic. Adherence to treatment guidelines is important. Pharmacists working in multidisciplinary teams may contribute to early detection and management of MA therapy‐related ADR.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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