Occupational Co-exposures to Multiple Chemical Agents from Workplace Measurements by the US Occupational Safety and Health Administration.
Objectives The occupational environment represents an important source of exposures to multiplehazards for workers' health. Although it is recognized that mixtures of agents may have differenteffects on health compared to their individual effects, studies generally focus on the assessment ofindividu...
| Publicado en: | Annals of Work Exposures & Health Vol. 64; no. 4; pp. 402 - 416 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
May2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143081750&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143081750 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23987308 KJ1E jtl: Annals of Work Exposures & Health issn: 23987308 maglogo: N pubinfo: dt: May2020 vid: 64 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 143081750 143081750 143081750 10.1093/annweh/wxaa008 143081750 ppf: 402 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Occupational Co-exposures to Multiple Chemical Agents from Workplace Measurements by the US Occupational Safety and Health Administration. aug: au: Bosson-Rieutort, Delphine Sarazin, Philippe Bicout, Dominique J Ho, Vikki Lavoué, Jérôme affil: Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre (CRCHUM), Montréal, Québec, Canada sug: subj: United States Occupational Safety and Health Administration Occupational Exposure Organic Chemicals Risk Assessment Methods Human Management Information Systems Work Environment Descriptive Statistics Solvents Metals ab: Objectives The occupational environment represents an important source of exposures to multiplehazards for workers' health. Although it is recognized that mixtures of agents may have differenteffects on health compared to their individual effects, studies generally focus on the assessment ofindividual exposures. Our objective was to identify occupational co-exposures occurring in the United States using the multi-industry occupational exposure databank of the Occupational Safety and Health Administration (OSHA). Methods Using OSHA's Integrated Management Information System (IMIS), measurement data from workplace inspections occurring from 1979 to 2015 were examined. We defined a workplace situation (WS) by grouping measurements that occurred within a company, within the same occupation (i.e. job title) within 1 year. All agents present in each WS were listed and the resulting databank was analyzed with the Spectrosome approach, a methodology inspired by network science, to determine global patterns of co-exposures. The presence of an agent in a WS was defined either as detected, or measured above 20% of a relevant occupational exposure limit (OEL). Results Among the 334 648 detected exposure measurements of 105 distinct agents collected from 14 513 US companies, we identified 125 551 WSs, with 31% involving co-exposure. Fifty-eight agents were detected with others in >50% of WSs, 29 with a proportion >80%. Two clusters were highlighted, one for solvents and one for metals. Toluene, xylene, acetone, hexone, 2-butanone, and N -butyl acetate formed the basis of the solvent cluster. The main agents of the metal cluster were zinc, iron, lead, copper, manganese, nickel, cadmium, and chromium. 68 556 WS were included in the analyses based on levels of exposure above 20% of their OEL, with 12.4% of co-exposure. In this analysis, while the metal cluster remained, only the combinations of toluene with xylene or 2-butanone were frequently observed among solvents. An online web application allows the examination of industry specific patterns. Conclusions We identified frequent co-exposure situations in the IMIS databank. Using the spectrome approach, we revealed global combination patterns and the agents most often implicated. Future work should endeavor to explore the toxicological effects of prevalent combinations of exposures on workers' health to prioritize research and prevention efforts. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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