Molecular Assessment of Kidney Allografts: Are We Closer to a Daily Routine?
Kidney allograft pathology assessment has been traditionally based on clinical and histological criteria. Despite improvements in Banff histological classification, the diagnostics in particular cases is problematic reflecting a complex pathogenesis of graft injuries. With the advent of molecular te...
| Publicado en: | Physiological Research Vol. 69; no. 2; pp. 215 - 227 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Institute of Physiology, Academy of Sciences of the Czech Republic
Apr2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143148147&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143148147 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08628408 1CVW jtl: Physiological Research issn: 08628408 maglogo: N pubinfo: dt: Apr2020 vid: 69 iid: 2 pid: 24634 pub: Institute of Physiology, Academy of Sciences of the Czech Republic artinfo: ui: 143148147 10.33549/physiolres.934278 143148147 ppf: 215 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Molecular Assessment of Kidney Allografts: Are We Closer to a Daily Routine? aug: au: TRAILIN, Andriy HRUBA, Petra VIKLICKY, Ondrej affil: Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic sug: ab: Kidney allograft pathology assessment has been traditionally based on clinical and histological criteria. Despite improvements in Banff histological classification, the diagnostics in particular cases is problematic reflecting a complex pathogenesis of graft injuries. With the advent of molecular techniques, polymerasechain reaction, oligo- and microarray technologies allowed to study molecular phenotypes of graft injuries, especially acute and chronic rejections. Moreover, development of the molecular microscope diagnostic system (MMDx) to assess kidney graft biopsies represents the first clinical application of a microarraybased method in transplantation. Whether MMDx may replace conventional pathology is the subject of ongoing research, however this platform is particularly useful in complex histological findings and may help clinicians to guide the therapy. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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