Pyoderma gangrenosum in hematologic malignancies: A systematic review.
Background: Pyoderma gangrenosum (PG) is a devastating neutrophilic dermatosis that may be associated with trauma or systemic diseases. The associations, characteristics, and temporal relationship of PG with hematologic malignancies are not well understood.Objective: We performed a systematic review...
| Publicado en: | Journal of the American Academy of Dermatology Vol. 82; no. 6; pp. 1346 - 1360 |
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| Autores principales: | , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143158608&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143158608 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01909622 1ZF jtl: Journal of the American Academy of Dermatology issn: 01909622 maglogo: N pubinfo: dt: Jun2020 vid: 82 iid: 6 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 143158608 143158608 NLM31560977 143158608 10.1016/j.jaad.2019.09.032 NLM31560977 143158608 ppf: 1346 ppct: 14 formats: tig: atl: Pyoderma gangrenosum in hematologic malignancies: A systematic review. aug: au: Montagnon, Carmen M. Fracica, Elizabeth A. Patel, Archna A. Camilleri, Michael J. Murad, M. Hassan Dingli, David Wetter, David A. Tolkachjov, Stanislav N. affil: Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota sug: subj: Pyoderma Gangrenosum Complications Monoclonal Gammopathy of Undetermined Significance Complications Myelodysplastic Syndromes Complications Hematologic Neoplasms Complications Hematologic Neoplasms Pathology Leukemia, Myeloid, Acute Complications Myelodysplastic Syndromes Pathology Pyoderma Gangrenosum Drug Therapy Human Systematic Review ab: Background: Pyoderma gangrenosum (PG) is a devastating neutrophilic dermatosis that may be associated with trauma or systemic diseases. The associations, characteristics, and temporal relationship of PG with hematologic malignancies are not well understood.Objective: We performed a systematic review of PG associated with hematologic malignancies using data from case reports, case series, and retrospective studies.Methods: We searched MEDLINE, EMBASE, Scopus, and Web of Science from each database's inception to December 12, 2018. Two reviewers independently selected studies and extracted data.Results: Two hundred seventy-nine publications met the inclusion criteria (340 cases). Myelodysplastic syndrome (MDS) was the most commonly reported hematologic malignancy associated with PG, followed by monoclonal gammopathy of undetermined significance and acute myeloid leukemia. The mean age of patients was 56.5 years, with males being more common. There was a predominance of the ulcerative PG subtype and multifocal distributions across all hematologic malignancies. The majority of MDS cases preceded PG, which was reversed for MGUS.Limitations: The data were limited by reporting bias because PG subtypes rely on the rendered diagnosis reported. In addition, the classification for hematologic malignancies has evolved since 1978.Conclusion: Patients with PG should be evaluated for hematologic malignancies, with MDS being the most common. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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