Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission.
The new glucosyl sarpagan alkaloid designated as 21(R *)-(O - β -glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectros...
| Publicado en: | Fitoterapia Vol. 143 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143160056&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143160056 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Jun2020 vid: 143 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 143160056 143160056 143160056 10.1016/j.fitote.2020.104545 143160056 ppct: 1 formats: tig: atl: Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. aug: au: Magalhães, Herbert S. da Silva, Alison B. Nascimento, Nilberto R.F. de Sousa, Luis Gustavo F. da Fonseca, Maria Júlia S. Loiola, Maria Iracema B. Monteiro, Norberto K.V. Almeida Neto, Francisco Wagner Q. Canuto, Kirley M. Pessoa, Otilia Deusdênia L. affil: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60971-270 Fortaleza, CE, Brazil sug: subj: Indoles Pharmacodynamics Alkaloids Pharmacodynamics Plant Roots Pharmacodynamics Neural Transmission Drug Effects Molecular Structure Magnetic Resonance Spectroscopy Chemistry, Analytical Neurotransmitter Agents Plants Animal Studies Mice Models, Biological Funding Source ab: The new glucosyl sarpagan alkaloid designated as 21(R *)-(O - β -glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alkaloids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1 , 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activity. Unlabelled Image pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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