Prediction and prevention of hypoglycaemic events in type-1 diabetic patients using machine learning.

Tight blood glucose control reduces the risk of microvascular and macrovascular complications in patients with type 1 diabetes. However, this is very difficult due to the large intra-individual variability and other factors that affect glycaemic control. The main limiting factor to achieve strict co...

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Published in:Health Informatics Journal Vol. 26; no. 1; pp. 703 - 719
Main Authors: Vehí, Josep, Contreras, Iván, Oviedo, Silvia, Biagi, Lyvia, Bertachi, Arthur
Format: equations & formulas pictorial research tables/charts Journal Article
Published: Sage Publications Inc. Mar2020
Online Access:View this record in EBSCOhost
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      dt: Mar2020
      vid: 26
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      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        10.1177/1460458219850682
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        atl: Prediction and prevention of hypoglycaemic events in type-1 diabetic patients using machine learning.
      aug:
        au:
          Vehí, Josep
          Contreras, Iván
          Oviedo, Silvia
          Biagi, Lyvia
          Bertachi, Arthur
        affil: Universitat de Girona, Spain
      sug:
        subj:
          Diabetes Mellitus, Type 1
          Hypoglycemia Prevention and Control
          Hypoglycemia Diagnosis
          Machine Learning Methods
          Risk Assessment
          Risk Management
          Human
          Hypoglycemia Risk Factors
          Glycemic Control
          Diabetic Patients Psychosocial Factors
          Quality of Life
          Decision Support Systems, Clinical
          Patient Safety
          Adverse Health Care Event
          Algorithms
          Blood Glucose Monitoring
          Vectorcardiography
          Neural Networks (Computer)
          Data Mining
          Exploratory Research
          Correlational Studies
          Sensitivity and Specificity
          Engineering
      ab: Tight blood glucose control reduces the risk of microvascular and macrovascular complications in patients with type 1 diabetes. However, this is very difficult due to the large intra-individual variability and other factors that affect glycaemic control. The main limiting factor to achieve strict control of glucose levels in patients on intensive insulin therapy is the risk of severe hypoglycaemia. Therefore, hypoglycaemia is the main safety problem in the treatment of type 1 diabetes, negatively affecting the quality of life of patients suffering from this disease. Decision support tools based on machine learning methods have become a viable way to enhance patient safety by anticipating adverse glycaemic events. This study proposes the application of four machine learning algorithms to tackle the problem of safety in diabetes management: (1) grammatical evolution for the mid-term continuous prediction of blood glucose levels, (2) support vector machines to predict hypoglycaemic events during postprandial periods, (3) artificial neural networks to predict hypoglycaemic episodes overnight, and (4) data mining to profile diabetes management scenarios. The proposal consists of the combination of prediction and classification capabilities of the implemented approaches. The resulting system significantly reduces the number of episodes of hypoglycaemia, improving safety and providing patients with greater confidence in decision-making.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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