Aberrant brain structural network and altered topological organization in minimal hepatic encephalopathy.
Purpose: We aimed to investigate the multilevel impairments of brain structural network in patients with minimal hepatic encephalopathy (MHE).Methods: Twenty-two patients with MHE and 22 well-matched healthy controls (HC) underwent structural magnetic resonance imaging (MRI) brain scans and neuropsy...
| Publicado en: | Diagnostic & Interventional Radiology Vol. 26; no. 3; pp. 255 - 262 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Galenos Yayinevi Tic. LTD. STI
May2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143352643&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143352643 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13053825 39NM jtl: Diagnostic & Interventional Radiology issn: 13053825 maglogo: N pubinfo: dt: May2020 vid: 26 iid: 3 pid: 28155 pub: Galenos Yayinevi Tic. LTD. STI artinfo: ui: 143352643 143352643 NLM32209507 10.5152/dir.2019.19216 NLM32209507 143352643 ppf: 255 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Aberrant brain structural network and altered topological organization in minimal hepatic encephalopathy. aug: au: Lu-Bin Gou Wei Zhang Da-Jing Guo Wei-Jia Zhong Xiao-Jia Wu Zhi-Ming Zhou Gou, Lu-Bin Zhang, Wei Guo, Da-Jing Zhong, Wei-Jia Wu, Xiao-Jia Zhou, Zhi-Ming affil: Department of Radiology, First Hospital of Lan Zhou University, Gansu, China sug: subj: Brain Mapping Methods Brain Magnetic Resonance Imaging Methods Hepatic Encephalopathy Physiopathology Case Control Studies Middle Age Neuropsychological Tests Standards Ammonia Blood Nervous System Physiopathology Male Female Aged Scales Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: We aimed to investigate the multilevel impairments of brain structural network in patients with minimal hepatic encephalopathy (MHE).Methods: Twenty-two patients with MHE and 22 well-matched healthy controls (HC) underwent structural magnetic resonance imaging (MRI) brain scans and neuropsychological evaluations. Individual brain structural networks were constructed using diffusion tensor imaging. Comparing with HC, we investigated the possible impairments of brain structural network in MHE, by applying graph-theory approaches to analyze the topological organization at global, modular, and local levels. The correlations between altered brain structural network and neuropsychological tests scores and venous ammonia levels were also examined in MHE patients.Results: In the MHE group, small-worldness showed significant decrease and normalized characteristic path length showed increase at the global level. In the modular section, six modules were identified. The inter-modular connective strengths showed significant increase between modules 2 and 4 and between modules 4 and 5. The results of node analysis showed similar hub distributions in the MHE and HC groups except for the right postcentral gyrus, which was only found in the MHE group. No significant differences were found in connective strength of edges between MHE and HC groups using network-based statistics.Conclusion: The altered brain structural networks with reduced network integration and module segregation were demonstrated in patients with MHE. The dysconnectivity of brain structural network could provide an explanation for the brain dysfunctions of MHE. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|