Preliminary study on the effects of treatment for breast cancer: immunological markers as they relate to quality of life and neuropsychological performance.
Background: Immunological biomarkers were related to quality of life and neuropsychological performance in women recently diagnosed with breast cancer through the first six months of treatment. A comparison group of breast cancer survivors in remission were also evaluated.Method: Twenty women newly...
| Publicado en: | BMC Women's Health Vol. 20; no. 1; pp. 1 - 15 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
5/20/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143358333&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143358333 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726874 1CIP jtl: BMC Women's Health issn: 14726874 maglogo: N pubinfo: dt: 5/20/2020 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 143358333 143358333 NLM32434503 143358333 10.1186/s12905-020-00971-1 NLM32434503 143358333 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Preliminary study on the effects of treatment for breast cancer: immunological markers as they relate to quality of life and neuropsychological performance. aug: au: Boivin, Michael J. Aaron, Geoffrey P. Felt, Nathan G. Shamoun, Lance affil: Department of Neurology & Ophthalmology, Michigan State University, East Lansing, USA sug: subj: Cognition Disorders Epidemiology Cytokines Blood Breast Neoplasms Drug Therapy Breast Neoplasms Immunology Quality of Life Psychosocial Factors Breast Neoplasms Complications Human Female Middle Age Breast Neoplasms Psychosocial Factors Treatment Outcomes Flow Cytometry Neuropsychological Tests Adult Validation Studies Comparative Studies Evaluation Research Multicenter Studies Ferrans and Powers Quality of Life Index Psychosocial Adjustment to Illness Scale Middle Aged: 45-64 years Adult: 19-44 years Female ab: Background: Immunological biomarkers were related to quality of life and neuropsychological performance in women recently diagnosed with breast cancer through the first six months of treatment. A comparison group of breast cancer survivors in remission were also evaluated.Method: Twenty women newly diagnosed with breast cancer and 26 breast cancer survivors at least a year after treatment were evaluated four times over a course of six to 8 months. The assessments included quality-of-life, emotional and spiritual well-being, sleep quality, computerized neuropsychological performance, and cytokine immunology biomarkers using flow cytometry. The principal immunological markers examined were the CD4+, CD8+, and CD16+ counts.Results: Although equivalent at enrollment, active treatment women reported higher anxiety, depression, poorer quality-of-life, and poorer processing speed and accuracy on memory, logical processes, and coding neuropsychological tasks. They also had significantly higher CD8+ and CD16+ cell count levels during treatment over the next six to eight months than comparison group women in remission. Women undergoing chemotherapy as well during treatment phase also had a significant decline in CD4+ counts. Higher percent CD8+ levels during treatment was associated with poorer quality of life and more depression, while higher CD4+ and CD8+ were associated with poorer neuropsychological memory and processing speed performance.Conclusion: Significant increases in CD8+ is a sensitive biomarker of a broad range of poorer quality-of-life and neurocognitive functioning outcomes during breast cancer treatment, especially in women undergoing chemotherapy. Quality of life should be monitored in breast cancer patients and psychosocial support made available as a standard of care. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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