Pharmacokinetics in children with chronic kidney disease.
In children, the main causes of chronic kidney disease (CKD) are congenital diseases and glomerular disorders. CKD is associated with multiple physiological changes and may therefore influence various pharmacokinetic (PK) parameters. A well-known consequence of CKD on pharmacokinetics is a reduction...
| Publicado en: | Pediatric Nephrology Vol. 35; no. 7; pp. 1153 - 1173 |
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| Autores principales: | , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143396692&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143396692 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Jul2020 vid: 35 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143396692 143396692 143396692 10.1007/s00467-019-04304-9 143396692 ppf: 1153 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pharmacokinetics in children with chronic kidney disease. aug: au: Schijvens, Anne M. de Wildt, Saskia N. Schreuder, Michiel F. affil: Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Radboud University Medical Center, Amalia Children's Hospital, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands sug: subj: Kidney Failure, Chronic In Infancy and Childhood Pharmacokinetics Glomerular Filtration Rate Drugs Metabolism Drug Toxicity Child Metabolic Clearance Rate Intestinal Absorption Child: 6-12 years ab: In children, the main causes of chronic kidney disease (CKD) are congenital diseases and glomerular disorders. CKD is associated with multiple physiological changes and may therefore influence various pharmacokinetic (PK) parameters. A well-known consequence of CKD on pharmacokinetics is a reduction in renal clearance due to a decrease in the glomerular filtration rate. The impact of renal impairment on pharmacokinetics is, however, not limited to a decreased elimination of drugs excreted by the kidney. In fact, renal dysfunction may lead to modifications in absorption, distribution, transport, and metabolism as well. Currently, insufficient evidence is available to guide dosing decisions on many commonly used drugs. Moreover, the impact of maturation on drug disposition and action should be taken into account when selecting and dosing drugs in the pediatric population. Clinicians should take PK changes into consideration when selecting and dosing drugs in pediatric CKD patients in order to avoid toxicity and increase efficiency of drugs in this population. The aim of this review is to summarize known PK changes in relation to CKD and to extrapolate available knowledge to the pediatric CKD population to provide guidance for clinical practice. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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