Independence of coronary artery disease to subclinical left ventricular dysfunction.
Objective: Epicardial atherosclerosis and heart failure while distinct clinical entities share common pathophysiological features including endothelial dysfunction and inflammation. Presence of subclinical disease could lead to early diagnosis and intervention in the other. The aim of our study was...
| Publicado en: | Echocardiography Vol. 37; no. 5; pp. 678 - 688 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143431706&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143431706 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: May2020 vid: 37 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 143431706 143431706 145873350 143431706 10.1111/echo.14657 143431706 ppf: 678 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Independence of coronary artery disease to subclinical left ventricular dysfunction. aug: au: Venkataraman, Prasanna Wright, Leah Huynh, Quan Marwick, Thomas H. affil: Baker Heart and Diabetes Research Institute, Melbourne Vic.,, Australia sug: subj: Coronary Arteriosclerosis Risk Factors Ventricular Dysfunction, Left Ultrasonography Coronary Vessels Pathology Calcinosis Cardiovascular Risk Factors Risk Assessment Echocardiography Human Adult Middle Age Aged Cardiac Patients Descriptive Statistics Tomography, X-Ray Computed Heart Atrium, Left Pathology Odds Ratio Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Objective: Epicardial atherosclerosis and heart failure while distinct clinical entities share common pathophysiological features including endothelial dysfunction and inflammation. Presence of subclinical disease could lead to early diagnosis and intervention in the other. The aim of our study was to assess the association between coronary calcium score (CCS), conventional cardiovascular risk factors, and echocardiographic markers of subclinical left ventricular dysfunction (S‐LVD). Methods: One hundred and fifty‐nine participants aged 40–70 years with intermediate risk of coronary artery disease (5‐year risk of 2%–15%) were identified. Computed tomography (CT) CCS and 2‐D transthoracic echocardiography were performed. Main outcomes included presence of subclinical left ventricular dysfunction defined by reduced average global longitudinal strain, left atrial volume enlargement, and elevated E/e'. Results: Fifteen participants had evidence of subclinical LV dysfunction (8 with systolic dysfunction and 7 with diastolic dysfunction) and 85 participants had CCS > 0. CCS > 0 was present in 10 participants with S‐LVD compared to 75 participants without S‐LVD (67% vs 53%, P =.47). There was no significant difference between in mean GLS (19.2 vs 19.5, P =.14), E/e' (7.2 vs 7.5 P =.33) in those without or with coronary artery calcium. Elevated CCS was also not associated with a higher tertiles of indexed LV mass (OR 1.15, P =.49) or index left atrial volume (OR 1.15, P =.49). Conclusions: In an asymptomatic, low‐intermediate‐risk group, mechanistic processes that lead to atherosclerosis are not directly associated with subclinical LV dysfunction. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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