SPECT Imaging of Muscle Injury with [99mTc]MDP in a Mouse Model of Muscular Dystrophy.
Purpose: Tc-99m methylene diphosphonate ([99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD)...
| Publicado en: | Molecular Imaging & Biology Vol. 22; no. 3; pp. 562 - 569 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143439691&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143439691 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2020 vid: 22 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143439691 143439691 NLM31286350 143439691 10.1007/s11307-019-01394-7 NLM31286350 143439691 ppf: 562 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: SPECT Imaging of Muscle Injury with [99mTc]MDP in a Mouse Model of Muscular Dystrophy. aug: au: Gaut, Carolynn Sullivan, Jenna M. Biscaro, Barbara Soares, Edward J. Nicholson, Katharine Hoppin, Jack Verma, Ajay affil: Invicro, Boston, MA, USA sug: subj: Muscular Dystrophy Muscles Radiopharmaceuticals Pharmacokinetics Muscles Injuries Muscles Metabolism Mice Muscular Dystrophy Pathology Models, Biological Muscular Dystrophy Metabolism Muscles Pathology Male Diagnostic Imaging Methods Animal Studies Radiopharmaceuticals Comparative Studies Multicenter Studies Evaluation Research Validation Studies Male ab: Purpose: Tc-99m methylene diphosphonate ([99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD).Procedures: Static whole-body single-photon emission computed tomography/computed tomography (CT) scans were acquired at 2 h post-injection of [99mTc]MDP in two cohorts of animals at different sites: one cohort of mice at 6, 15, and 19 weeks of age, and a separate cohort at 16 weeks. The second cohort was also imaged with high-resolution CT at 8 weeks.Results: mdx mice had higher [99mTc]MDP uptake and significantly higher [99mTc]MDP concentrations in muscle than controls.Conclusions: Higher uptake of [99mTc]MDP in muscle of mdx mice agrees with histological reports of muscle calcification in mdx mice, and suggests the potential translational use of [99mTc]MDP imaging for tracking DMD progression and therapeutic response. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|