A Preliminary Investigation into the Use of Edge Illumination X-ray Phase Contrast Micro-CT for Preclinical Imaging.
Purpose: To enable a preliminary assessment of the suitability of edge illumination (EI) x-ray phase contrast (XPC) micro x-ray computed tomography (micro-CT) to preclinical imaging. Specifically, to understand how different acquisition schemes and their combination with dedicated data processing af...
| Publicado en: | Molecular Imaging & Biology Vol. 22; no. 3; pp. 539 - 549 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143439692&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143439692 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2020 vid: 22 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143439692 143439692 NLM31250331 143439692 10.1007/s11307-019-01396-5 NLM31250331 143439692 ppf: 539 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A Preliminary Investigation into the Use of Edge Illumination X-ray Phase Contrast Micro-CT for Preclinical Imaging. aug: au: Hagen, Charlotte K. Endrizzi, Marco Towns, Rebecca Meganck, Jeffrey A. Olivo, Alessandro affil: Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, WC1E 6BT, London, UK sug: subj: Tomography, X-Ray Computed Methods Image Processing, Computer Assisted Methods Microscopy Methods Diagnostic Imaging Methods Sensitivity and Specificity Animal Studies Radiation Dosage Mice Algorithms Comparative Studies Multicenter Studies Evaluation Research Validation Studies Funding Source ab: Purpose: To enable a preliminary assessment of the suitability of edge illumination (EI) x-ray phase contrast (XPC) micro x-ray computed tomography (micro-CT) to preclinical imaging. Specifically, to understand how different acquisition schemes and their combination with dedicated data processing affect contrast-to-noise ratio (CNR) and spatial resolution, while providing control over scan time and radiation dose delivery.Procedures: Deceased mice (n = 3) were scanned with an EI XPC micro-CT setup operated under different settings, leading to scan times between 18 h and 13 min. For the shortest scan, the entrance dose was measured with a calibrated PTW 23344 ion chamber. Different data processing methods were applied, retrieving either separate attenuation and phase images, or hybrid (combined attenuation and phase) images. A quantitative comparison was performed based on CNR and spatial resolution measurements for a soft tissue interface.Results: All phase-based images have led to a higher CNR for the considered soft tissue interface than the attenuation image, independent of scan time. The best relative CNR (a sixfold increase) was observed in one of the hybrid images. Spatial resolution was found to be connected to scan time, with a resolution of approximately 20 μm and 60 μm achieved for the longest and shortest scans, respectively. An entrance dose of approximately 300 mGy was estimated for the scan performed within 13 min.Conclusions: Despite their preliminary nature, our results suggest that EI XPC bears potential for enhancing the utility of preclinical micro-CT, and, pending further research and development, could ultimately become a valuable technique in this field. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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