Preoperative Prediction of Extracapsular Extension: Radiomics Signature Based on Magnetic Resonance Imaging to Stage Prostate Cancer.
Purpose: To investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).Procedures: The preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients...
| Publicado en: | Molecular Imaging & Biology Vol. 22; no. 3; pp. 711 - 722 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143439697&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143439697 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2020 vid: 22 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143439697 143439697 NLM31321651 143439697 10.1007/s11307-019-01405-7 NLM31321651 143439697 ppf: 711 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Preoperative Prediction of Extracapsular Extension: Radiomics Signature Based on Magnetic Resonance Imaging to Stage Prostate Cancer. aug: au: Ma, Shuai Xie, Huihui Wang, Huihui Yang, Jiejin Han, Chao Wang, Xiaoying Zhang, Xiaodong affil: Department of Radiology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, 100034, Beijing, China sug: subj: Prostatic Neoplasms Prostatic Neoplasms Pathology Image Processing, Computer Assisted Methods Magnetic Resonance Imaging Methods Male Aged ROC Curve Predictive Value of Tests Retrospective Design Human Preoperative Care Methods Neoplasm Staging Comparative Studies Multicenter Studies Evaluation Research Validation Studies Funding Source Aged: 65+ years Male ab: Purpose: To investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).Procedures: The preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients were retrospectively assessed. The samples with were randomized in a two-to-one ratio into training (n = 74) and validation (n = 45) datasets. The radiomics features were derived from T2-weighted images (T2WIs). The optimal radiomics features were identified from the least absolute shrinkage and selection operator (LASSO) logistic regression model and were used to construct a predictive radiomics signature via dimension reduction and selection approaches. The association between the radiomics signatures and pathological ECE status was explored. Receiver operating characteristic (ROC) analysis was used to assess the discriminatory ability of the signature. The calibration performance and clinical usefulness of the radiomics signature were subsequently assessed by calibration curve and decision curve analyses.Results: The proposed radiomics signature that incorporated 17 selected radiomics features was significantly associated with pathological ECE outcomes (P < 0.001) in both the training and validation datasets. The constructed model displayed good discrimination, with areas under the curve (AUC) of 0.906 (95 % confidence interval (CI), 0.847, 0.948) and 0.821 (95 % CI, 0.726, 0.894) for the training and validation datasets, respectively, and had a good calibration performance. The clinical utility of this model was confirmed through decision curve analysis.Conclusions: The radiomics signature based on T2WIs showed the potential to predict the side-specific probability of pathological ECE status and can facilitate the preoperative individualized predictions for PCa patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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