The Current Role of Microfluidics in Radiofluorination Chemistry.
The current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review...
| Published in: | Molecular Imaging & Biology Vol. 22; no. 3; pp. 463 - 476 |
|---|---|
| Main Authors: | , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Jun2020
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143439706&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143439706 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2020 vid: 22 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143439706 143439706 NLM31485889 143439706 10.1007/s11307-019-01414-6 NLM31485889 143439706 ppf: 463 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Current Role of Microfluidics in Radiofluorination Chemistry. aug: au: Knapp, Karla-Anne Nickels, Michael L. Manning, H. Charles affil: Department of Chemistry, Vanderbilt University, Nashville, TN, USA sug: subj: Fluorine Radioisotopes Radiopharmaceuticals Isotopes Microfluidics Methods Tomography, Emission-Computed Methods Human Animal Studies Microfluidics Equipment and Supplies Comparative Studies Multicenter Studies Evaluation Research Validation Studies Clinical Assessment Tools Funding Source ab: The current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review, we summarize the current status of microfluidic radiosynthesis units for producing fluorine-18 labeled PET imaging tracers, including a discussion of the relative strengths and weaknesses of such devices. In addition, we provide a brief overview of the radiotracers that have been produced using microfluidic devices to date. Finally, we discuss the prospects for the future of this field, including the potential of newly envisioned devices developed that may allow operators to easily synthesize specialized tracers for individual patient doses. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|