Cryptococcus meningitis mimicking cerebral septic emboli, a case report series demonstrating injection drug use as a risk factor for development of disseminated disease.

Background: Clinicians may be less inclined to consider a diagnosis of cryptococcal meningitis in people without HIV infection or transplant-related immunosuppression. This may lead to a delay in diagnosis particularly if disseminated cryptococcal disease mimics cerebral septic emboli in injection d...

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Publicado en:BMC Infectious Diseases Vol. 20; no. 1; pp. 1 - 6
Autores principales: Polk, Christopher, Meredith, Jacqueline, Kuprenas, Alyssa, Leonard, Michael
Formato: case study Journal Article
Publicado: BioMed Central 5/27/2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 5/27/2020
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      pub: BioMed Central
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        10.1186/s12879-020-05108-1
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        143453773
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        atl: Cryptococcus meningitis mimicking cerebral septic emboli, a case report series demonstrating injection drug use as a risk factor for development of disseminated disease.
      aug:
        au:
          Polk, Christopher
          Meredith, Jacqueline
          Kuprenas, Alyssa
          Leonard, Michael
        affil: Atrium Health Department of Medicine, Charlotte, NC, USA
      sug:
        subj:
          Meningitis, Cryptococcal Diagnosis
          Intracranial Embolism Microbiology
          Substance Use Disorders Complications
          Intracranial Embolism Immunology
          Cryptococcus
          Middle Age
          Intracranial Embolism Diagnosis
          Meningitis, Cryptococcal Immunology
          Meningitis, Cryptococcal Microbiology
          Intracranial Embolism Etiology
          Male
          Risk Factors
          Meningitis, Cryptococcal Etiology
          Adult
          Study Design
          Middle Aged: 45-64 years
          Adult: 19-44 years
          Male
      ab: Background: Clinicians may be less inclined to consider a diagnosis of cryptococcal meningitis in people without HIV infection or transplant-related immunosuppression. This may lead to a delay in diagnosis particularly if disseminated cryptococcal disease mimics cerebral septic emboli in injection drug use (IDU) leading to a search for endocarditis or other infectious sources. Though, IDU has been described as a potential risk for disseminated cryptococcal disease.Case Presentations: We present two cases of cryptococcal meningitis in IDU without HIV or other obvious immune deficits. Both patients presented with at least 2 weeks of headache and blurred vision. They developed central nervous system (CNS) vasculitis, one of which mimicked septic cerebral emboli, but both resulted with poor neurologic outcomes.Conclusions: IDU likely induces an underappreciated immune deficit and is a risk factor for developing cryptococcal meningitis. This diagnosis, which can mimic cerebral septic emboli through involvement of a CNS vasculitis, should be considered in the setting of IDU.
      pubtype: Academic Journal
      doctype:
        case study
        Journal Article
      ougenre: Article
    language: English
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