Relationships of p16 Immunohistochemistry and Other Biomarkers With Diagnoses of Cervical Abnormalities: Implications for LAST Terminology.
* Context.--Lower Anogenital Squamous Terminology (LAST) standardization recommended p16INK4a immunohistochemistry (p16 IHC) for biopsies diagnosed morphologically as cervical intraepithelial neoplasia (CIN) grade 2 (CIN2) to classify them as low-grade or high-grade squamous intraepithelial lesions...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 144; no. 6; pp. 725 - 735 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143462128&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143462128 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jun2020 vid: 144 iid: 6 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 143462128 143462128 143462128 10.5858/arpa.2019-0241-OA 143462128 ppf: 725 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Relationships of p16 Immunohistochemistry and Other Biomarkers With Diagnoses of Cervical Abnormalities: Implications for LAST Terminology. aug: au: Castle, Philip E. Adcock, Rachael Cuzick, Jack Wentzensen, Nicolas Torrez-Martinez, Norah E. Torres, Salina M. Stoler, Mark H. Ronnett, Brigitte M. Joste, Nancy E. Darragh, Teresa M. Gravitt, Patti E. Schiffman, Mark Hunt, William C. Kinney, Walter K. Wheeler, Cosette M. affil: Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York sug: subj: Cervix Dysplasia Diagnosis Immunohistochemistry Methods Tumor Markers, Biological Cervix Neoplasms Diagnosis Human Carcinoma, Squamous Cell Stratified Random Sample Biopsy Papillomaviruses Genotype Proteins Metabolism ab: * Context.--Lower Anogenital Squamous Terminology (LAST) standardization recommended p16INK4a immunohistochemistry (p16 IHC) for biopsies diagnosed morphologically as cervical intraepithelial neoplasia (CIN) grade 2 (CIN2) to classify them as low-grade or high-grade squamous intraepithelial lesions (HSILs). Objective.--To describe the relationships of p16 IHC and other biomarkers associated with cervical cancer risk with biopsy diagnoses. Design.--A statewide, stratified sample of cervical biopsies diagnosed by community pathologists (CPs), including 1512 CIN2, underwent a consensus, expert pathologist panel (EP) review (without p16 IHC results), p16 IHC interpretation by a third pathology group, and human papillomavirus (HPV) genotyping, results of which were grouped hierarchically according to cancer risk. Antecedent cytologic interpretations were also available. Results.--Biopsies were more likely to test p16 IHC positive with increasing severity of CP diagnoses, overall (Ptrend ≤ .001) and within each HPV risk group (Ptrend ≤ .001 except for low-risk HPV [Ptrend < .010]). All abnormal grades of CP-diagnosed biopsies were more likely to test p16 IHC positive with a higher HPV risk group (Ptrend < .001), and testing p16 IHC positive was associated with higher HPV risk group than testing p16 IHC negative for each grade of CP-diagnosed biopsies (P < .001). p16 IHC--positive, CP-diagnosed CIN2 biopsies were less likely than CP-diagnosed CIN3 biopsies to test HPV16 positive, have an antecedent HSIL+ cytology, or to be diagnosed as CIN3+ by the EP (P < .001 for all). p16 IHC--positive, CP-diagnosed CIN1 biopsies had lower HPV risk groups than p16 IHC--negative, CP-diagnosed CIN2 biopsies (P < .001). Conclusions.--p16 IHC--positive, CP-diagnosed CIN2 appears to be lower cancer risk than CP-diagnosed CIN3. LAST classification of "HSIL" diagnosis, which includes p16 IHC--positive CIN2, should annotate the morphologic diagnosis (CIN2 or CIN3) to inform all management decisions, which is especially important for young (,30 years) women diagnosed with CIN2 for whom surveillance rather than treatment is recommended. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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