Patterns and Direct/Indirect Signaling Pathways in Cardiovascular System in the Condition of Transient Increase of NO.
Aim. To study "patterns" and connections of signaling pathways derived from the rat arterial pulse waveform (APW) under the condition of transient NO increase. Methods and Results. The right jugular vein of anesthetized Wistar rats was cannulated for administration of NO donor S-nitrosoglutathione....
| Publicado en: | BioMed Research International pp. 1 - 17 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | equations & formulas research tables/charts tracings Journal Article |
| Publicado: |
Wiley-Blackwell
5/28/2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143474555&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143474555 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 5/28/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 143474555 143474555 143474555 10.1155/2020/6578213 143474555 ppf: 1 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Patterns and Direct/Indirect Signaling Pathways in Cardiovascular System in the Condition of Transient Increase of NO. aug: au: Misak, Anton Kurakova, Lucia Berenyiova, Andrea Tomasova, Lenka Grman, Marian Cacanyiova, Sona Ondrias, Karol affil: Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia sug: subj: Glutathione Administration and Dosage Nitric Oxide Metabolism Signal Transduction Cardiovascular System Physiology Arterial Pressure Evaluation Blood Flow Velocity Evaluation Animal Studies Rats Jugular Veins Anesthetics Carotid Arteries Physiology Systolic Pressure Evaluation Hemodynamics ab: Aim. To study "patterns" and connections of signaling pathways derived from the rat arterial pulse waveform (APW) under the condition of transient NO increase. Methods and Results. The right jugular vein of anesthetized Wistar rats was cannulated for administration of NO donor S-nitrosoglutathione. The left carotid artery was cannulated to detect APW. From rat APW, 35 hemodynamic parameters (HPs) and several their crossrelationships were evaluated. We introduced a new methodology to study "patterns" and connections of different signaling pathways, which are suggested from hysteresis and nonhysteresis crossrelationships of 35 rat HPs. Here, we show parallel time-dependent patterns of 35 HPs and some of their crossrelationships under the condition of transient increase of NO bioavailability by administration of S-nitrosoglutathione. Approximate nonhysteresis relationships were observed between systolic blood pressure and at least 11 HPs suggesting that these HPs, i.e., their signaling pathways, responding to NO concentration, are directly connected. Hysteresis relationships were observed between systolic blood pressure and at least 14 HPs suggesting that the signaling pathways of these HPs are indirectly connected. Totally, from the crossrelationships of 35 HPs, one can obtain 595 "patterns" and indication of direct or indirect connections between the signaling pathways. Conclusion. We described the procedure leading virtually to 595 relationships, from which "patterns" for transient NO increase and direct or indirect connections of signaling pathways can be suggested. From a clinical perspective, this approach may be used in animal models and in humans to create a data bank of patterns of crossrelationships of HPs for different cardiovascular conditions. By comparison with unknown patterns of studied APW with the data bank patterns, it would be possible to determine cardiovascular conditions of the studied subject from the recorded arterial blood pressure. Additionally, it can help to find molecular mechanism of particular (patho-) physiological conditions or drug action and may have predictive or diagnostic value. pubtype: Academic Journal doctype: equations & formulas research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|