Conventional Machine Learning and Deep Learning Approach for Multi-Classification of Breast Cancer Histopathology Images—a Comparative Insight.

Automatic multi-classification of breast cancer histopathological images has remained one of the top-priority research areas in the field of biomedical informatics, due to the great clinical significance of multi-classification in providing diagnosis and prognosis of breast cancer. In this work, two...

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Publicado en:Journal of Digital Imaging Vol. 33; no. 3; pp. 632 - 655
Autores principales: Sharma, Shallu, Mehra, Rajesh
Formato: equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature Jun2020
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2020
      vid: 33
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-019-00307-y
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        atl: Conventional Machine Learning and Deep Learning Approach for Multi-Classification of Breast Cancer Histopathology Images—a Comparative Insight.
      aug:
        au:
          Sharma, Shallu
          Mehra, Rajesh
        affil: ECE Department, NITTTR, 160019, Chandigarh, India
      sug:
        subj:
          Machine Learning
          Deep Learning
          Automation
          Breast Neoplasms Diagnosis
          Image Processing, Computer Assisted Methods
          Histological Techniques Methods
          Human
          Female
          Comparative Studies
          Neoplasms, Fibrous Tissue Diagnosis
          Mucous Membrane Pathology
          Breast Neoplasms Classification
          Sensitivity and Specificity
          Female
      ab: Automatic multi-classification of breast cancer histopathological images has remained one of the top-priority research areas in the field of biomedical informatics, due to the great clinical significance of multi-classification in providing diagnosis and prognosis of breast cancer. In this work, two machine learning approaches are thoroughly explored and compared for the task of automatic magnification-dependent multi-classification on a balanced BreakHis dataset for the detection of breast cancer. The first approach is based on handcrafted features which are extracted using Hu moment, color histogram, and Haralick textures. The extracted features are then utilized to train the conventional classifiers, while the second approach is based on transfer learning where the pre-existing networks (VGG16, VGG19, and ResNet50) are utilized as feature extractor and as a baseline model. The results reveal that the use of pre-trained networks as feature extractor exhibited superior performance in contrast to baseline approach and handcrafted approach for all the magnifications. Moreover, it has been observed that the augmentation plays a pivotal role in further enhancing the classification accuracy. In this context, the VGG16 network with linear SVM provides the highest accuracy that is computed in two forms, (a) patch-based accuracies (93.97% for 40×, 92.92% for 100×, 91.23% for 200×, and 91.79% for 400×); (b) patient-based accuracies (93.25% for 40×, 91.87% for 100×, 91.5% for 200×, and 92.31% for 400×) for the classification of magnification-dependent histopathological images. Additionally, "Fibro-adenoma" (benign) and "Mucous Carcinoma" (malignant) classes have been found to be the most complex classes for the entire magnification factors.
      pubtype: Academic Journal
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      ougenre: Article
    language: English
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