Interactive, Up-to-date Meta-Analysis of MRI in the Management of Men with Suspected Prostate Cancer.

The aim of this study was to test an interactive up-to-date meta-analysis (iu-ma) of studies on MRI in the management of men with suspected prostate cancer. Based on the findings of recently published systematic reviews and meta-analyses, two freely accessible dynamic meta-analyses (https://iu-ma.or...

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Published in:Journal of Digital Imaging Vol. 33; no. 3; pp. 586 - 595
Main Authors: Becker, Anton S., Kirchner, Julian, Sartoretti, Thomas, Ghafoor, Soleen, Woo, Sungmin, Suh, Chong Hyun, Erinjeri, Joseph P., Hricak, Hedvig, Vargas, H. Alberto
Format: meta analysis pictorial research Journal Article
Published: Springer Nature Jun2020
Online Access:View this record in EBSCOhost
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      dt: Jun2020
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-019-00312-1
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        atl: Interactive, Up-to-date Meta-Analysis of MRI in the Management of Men with Suspected Prostate Cancer.
      aug:
        au:
          Becker, Anton S.
          Kirchner, Julian
          Sartoretti, Thomas
          Ghafoor, Soleen
          Woo, Sungmin
          Suh, Chong Hyun
          Erinjeri, Joseph P.
          Hricak, Hedvig
          Vargas, H. Alberto
        affil: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA
      sug:
        subj:
          Magnetic Resonance Imaging Methods
          Prostatic Neoplasms Diagnosis
          Disease Management
          Men's Health
          Human
          Male
          Meta Analysis
          PubMed
          Embase
          Physicians
          Biopsy Methods
          Ultrasonic Therapy Methods
          Medical Practice, Evidence-Based
          Male
      ab: The aim of this study was to test an interactive up-to-date meta-analysis (iu-ma) of studies on MRI in the management of men with suspected prostate cancer. Based on the findings of recently published systematic reviews and meta-analyses, two freely accessible dynamic meta-analyses (https://iu-ma.org) were designed using the programming language R in combination with the package "shiny." The first iu-ma compares the performance of the MRI-stratified pathway and the systematic transrectal ultrasound-guided biopsy pathway for the detection of clinically significant prostate cancer, while the second iu-ma focuses on the use of biparametric versus multiparametric MRI for the diagnosis of prostate cancer. Our iu-mas allow for the effortless addition of new studies and data, thereby enabling physicians to keep track of the most recent scientific developments without having to resort to classical static meta-analyses that may become outdated in a short period of time. Furthermore, the iu-mas enable in-depth subgroup analyses by a wide variety of selectable parameters. Such an analysis is not only tailored to the needs of the reader but is also far more comprehensive than a classical meta-analysis. In that respect, following multiple subgroup analyses, we found that even for various subgroups, detection rates of prostate cancer are not different between biparametric and multiparametric MRI. Secondly, we could confirm the favorable influence of MRI biopsy stratification for multiple clinical scenarios. For the future, we envisage the use of this technology in addressing further clinical questions of other organ systems.
      pubtype: Academic Journal
      doctype:
        meta analysis
        pictorial
        research
        Journal Article
      ougenre: Article
    language: English
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