Ethnic disparities in the frequency of cancer reported in family histories.
This study was designed to observe whether disparities exist between ethnicities in reporting a family history of cancer in a cancer genetic counseling clinic. Four hundred sixty‐nine pedigrees collected between 2015 to 2017 from a cancer clinic at the University of California, Irvine, were analyzed...
| Publicado en: | Journal of Genetic Counseling Vol. 29; no. 3; pp. 451 - 460 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143570263&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143570263 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10597700 41A jtl: Journal of Genetic Counseling issn: 10597700 maglogo: N pubinfo: dt: Jun2020 vid: 29 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 143570263 143570263 145822530 143570263 10.1002/jgc4.1264 143570263 ppf: 451 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Ethnic disparities in the frequency of cancer reported in family histories. aug: au: Maves, Heather Flodman, Pamela Nathan, Deepika Smith, Moyra affil: Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, Irvine California, sug: subj: Neoplasms Familial and Genetic Genetic Counseling Family History Truth Disclosure Ethnic Groups Race Factors Human Pedigree Regression Hispanic Americans Asians Jews Descriptive Statistics Forecasting Cancer Screening Risk Assessment ab: This study was designed to observe whether disparities exist between ethnicities in reporting a family history of cancer in a cancer genetic counseling clinic. Four hundred sixty‐nine pedigrees collected between 2015 to 2017 from a cancer clinic at the University of California, Irvine, were analyzed. Pedigrees were separated by ethnicity into the following categories: non‐Hispanic White, Hispanic, Asian, or Ashkenazi Jewish. The number of first‐ and second‐degree relatives was calculated for each pedigree, and the total number of relatives reported with cancer. The total reported with cancer was divided by total number of relatives to derive a percentage of cancer reporting for each pedigree. The percentages of cancer reporting were analyzed using column proportions, nonparametric tests, and a Poisson regression. Cancer reporting in first‐ and second‐degree relatives was highest among non‐Hispanic Whites and Ashkenazi Jewish individuals, with median percentages of 22% and 27%, respectively. The median percentage of cancer reporting in first‐ and second‐degree relatives in both Hispanics and Asians was 10%. Cancer reporting medians were significantly lower in Hispanics and Asians when compared to non‐Hispanic Whites and Ashkenazi Jewish individuals (p <.001). Ethnicity was a significant factor for predicting the number of relatives reported to have cancer when analyzed with a Poisson regression. This study concluded that cancer is reported less frequently in families when the proband and their families are Hispanic or Asian. Hispanics and Asians have lower cancer incidence rates; however, incidence rates alone may not explain the reporting disparity observed. Hence, family cancer histories in minority populations may be truncated. Healthcare professionals should be aware of this disparity when assessing cancer risks so appropriate modifications can be made accordingly for recommended cancer screening and/or cancer genetic testing. Further efforts are warranted to disseminate information to minority populations about the value of family health history regarding cancer risk assessment. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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