Assessment of cerebral low-frequency oscillations in patients with retinal vein occlusion: a preliminary functional MRI study.
Background: There is increasing evidence that patients with retinal vein occlusion exhibit cerebral vascular changes and are at an increased risk of stroke. However, it remains unknown whether patients with retinal vein occlusion exhibit changes in intrinsic brain activity.Purpose: This study invest...
| Publicado en: | Acta Radiologica Vol. 61; no. 6; pp. 813 - 821 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jun2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143609786&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143609786 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02841851 1XG jtl: Acta Radiologica issn: 02841851 maglogo: Y pubinfo: dt: Jun2020 vid: 61 iid: 6 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 143609786 143609786 NLM31604375 143609786 10.1177/0284185119879683 NLM31604375 143609786 ppf: 813 ppct: 8 formats: tig: atl: Assessment of cerebral low-frequency oscillations in patients with retinal vein occlusion: a preliminary functional MRI study. aug: au: Gao, Qing Peng, Bin Huang, Xin Qi, Chen-Xing Tong, Yan Deng, Qin-Qin Shen, Yin affil: Eye Center, 117921 -->Renmin Hospital of Wuhan University -->, Wuhan, Hubei, PR China sug: subj: Brain Retinal Vein Occlusion Physiopathology Brain Physiopathology Magnetic Resonance Imaging Methods Brain Mapping Methods Female Male Middle Age Human Middle Aged: 45-64 years Female Male ab: Background: There is increasing evidence that patients with retinal vein occlusion exhibit cerebral vascular changes and are at an increased risk of stroke. However, it remains unknown whether patients with retinal vein occlusion exhibit changes in intrinsic brain activity.Purpose: This study investigated intrinsic brain activity changes in patients with retinal vein occlusion by assessing the amplitude of low-frequency fluctuations.Material and Methods: Forty-five patients with retinal vein occlusion (22 men, 23 women, mean age 56.55 ± 6.97 years) and 43 healthy controls (13 men, 30 women; mean age 53.53 ± 8.19 years) closely matched in age, sex, and education level underwent resting-state MRI scans. The amplitude of low-frequency fluctuation method was used to compare intrinsic brain activity between the two groups.Results: Compared with healthy controls, patients with retinal vein occlusion exhibited significantly lower amplitude of low-frequency fluctuation values in the left middle occipital gyrus, right middle occipital gyrus, and right calcarine. However, patients with retinal vein occlusion showed significantly higher amplitude of low-frequency fluctuations in the bilateral cerebellum 6, right hippocampus, left insula, and left fusiform (voxel-level P < 0.01, Gaussian random field correction, cluster-level P < 0.05).Conclusion: Our results demonstrated that patients with retinal vein occlusion showed abnormal spontaneous neural activities in the visual cortices, cerebellum, and Papez circuit, which might indicate impaired vision, cognition, and emotional function in patients with retinal vein occlusion. These findings offer important insights into the neural mechanism of retinal vein occlusion. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|