A preliminary investigation of corpus callosum subregion white matter vulnerability and relation to chronic outcome in boxers.
Microstructural neuropathology occurs in the corpus callosum (CC) after repetitive sports concussion in boxers and can be dose-dependent. However, the specificity and relation of CC changes to boxing exposure extent and post-career psychiatric and neuropsychological outcomes are largely unknown. Usi...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 3; pp. 772 - 787 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143612130&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143612130 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2020 vid: 14 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143612130 143612130 NLM30565025 10.1007/s11682-018-0018-7 NLM30565025 143612130 ppf: 772 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A preliminary investigation of corpus callosum subregion white matter vulnerability and relation to chronic outcome in boxers. aug: au: Ware, Ashley L. Wilde, Elisabeth A. Newsome, Mary R. Moretti, Paolo Abildskov, Tracy Vogt, Gregory S. McCauley, Stephen R. Hanten, Gerri Hunter, Jill V. Chu, Zili D. Levin, Harvey S. affil: Department of Psychology and Texas Institute for Measurement, Evaluation and Statistics, University of Houston, 77204-6022, Houston, TX, USA sug: subj: Brain Magnetic Resonance Imaging Middle Age Telencephalon Adult Scales Middle Aged: 45-64 years Adult: 19-44 years ab: Microstructural neuropathology occurs in the corpus callosum (CC) after repetitive sports concussion in boxers and can be dose-dependent. However, the specificity and relation of CC changes to boxing exposure extent and post-career psychiatric and neuropsychological outcomes are largely unknown. Using deterministic diffusion tensor imaging (DTI) techniques, boxers and demographically-matched, noncontact sport athletes were compared to address literature gaps. Ten boxers and 9 comparison athletes between 26 and 59 years old (M = 44.63, SD = 9.24) completed neuropsychological testing and MRI. Quantitative DTI metrics were estimated for CC subregions. Group×Region interaction effects were observed on fractional anisotropy (FA; η2p ≥ .21). Follow-up indicated large effects of group (η2p ≥ .26) on splenium FA (boxers<comparisons) and genu mean diffusivity (MD; boxers>comparisons), but not radial diffusivity (RD). The group of boxers had moderately elevated number of psychiatric symptoms and reduced neuropsychological scores relative to the comparison group. In boxers, years sparring, professional bouts, and knockout history correlated strongly (r > |.40|) with DTI metrics and fine motor dexterity. In the comparison group, splenium FA correlated positively with psychiatric symptoms. In the boxer group, neuropsychological scores correlated with DTI metrics in all CC subregions. Results suggested relative vulnerability of the splenium and, to a lesser extent, the genu to chronic, repetitive head injury from boxing. Dose-dependent associations of professional boxing history extent with DTI white matter structure indices as well as fine motor dexterity were supported. Results indicated that symptoms of depression and executive dysfunction may provide the strongest indicators of global CC disruption from boxing. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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