Morphological changes in subregions of hippocampus and amygdala in major depressive disorder patients.
Despite many neuroimaging studies in the past years, the neuroanatomical substrates of major depressive disorder (MDD) subcortical structures are still not well understood. Since hippocampus and amygdala are the two vital subcortical structures that most susceptible to MDD, finding the evidence of m...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 3; pp. 653 - 668 |
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| Autores principales: | , , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143612137&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143612137 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2020 vid: 14 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143612137 143612137 NLM30519998 143612137 10.1007/s11682-018-0003-1 NLM30519998 143612137 ppf: 653 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Morphological changes in subregions of hippocampus and amygdala in major depressive disorder patients. aug: au: Yao, Zhijun Fu, Yu Wu, Jianfeng Zhang, Wenwen Yu, Yue Zhang, Zicheng Wu, Xia Wang, Yalin Hu, Bin affil: School of Information Science and Engineering, Lanzhou University, P.O. Box 730000, Lanzhou, China sug: subj: Depression Depression Pathology Basal Ganglia Hippocampus Pathology Hippocampus Basal Ganglia Pathology Atrophy Pathology Magnetic Resonance Imaging Human Funding Source Hamilton Rating Scale for Depression Psychological Tests ab: Despite many neuroimaging studies in the past years, the neuroanatomical substrates of major depressive disorder (MDD) subcortical structures are still not well understood. Since hippocampus and amygdala are the two vital subcortical structures that most susceptible to MDD, finding the evidence of morphological changes in their subregions may bring some new insights for MDD research. Combining structural magnetic resonance imaging (MRI) with novel morphometry analysis methods, we recruited 25 MDD patients and 28 healthy controls (HC), and investigated their volume and morphological differences in hippocampus and amygdala. Relative to volumetric method, our methods detected more significant global morphological atrophies (p<0.05). More precisely, subiculum and cornu ammonis (CA) 1 subregions of bilateral hippocampus, lateral (LA) and basolateral ventromedial (BLVM) of left amygdala and LA, BLVM, central (CE), amygdalostriatal transition area (ASTR), anterior cortical (ACO) and anterior amygdaloid area (AAA) of right amygdala were demonstrated prone to atrophy. Correlation analyses between each subject's surface eigenvalues and Hamilton Depression Scale (HAMD) were then performed. Correlation results showed that atrophy areas in hippocampus and amygdala have slight tendencies of expanding into other subregions with the development of MDD. Finally, we performed group morphometric analysis and drew the atrophy and expansion areas between MDD-Medicated group (only 19 medicated subjects in MDD group were included) and HC group, found some preliminary evidence about subregional morphological resilience of hippocampus and amygdala. These findings revealed new pathophysiologic patterns in the subregions of hippocampus and amygdala, which can help with subsequent smaller-scale MDD research. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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