Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography.
The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MR...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 3; pp. 696 - 715 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143612144&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143612144 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2020 vid: 14 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143612144 143612144 NLM30617788 143612144 10.1007/s11682-018-0006-y NLM30617788 143612144 ppf: 696 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography. aug: au: Dalamagkas, Kyriakos Tsintou, Magdalini Rathi, Yogesh O'Donnell, Lauren J. Pasternak, Ofer Gong, Xue Zhu, Anne Savadjiev, Peter Papadimitriou, George M. Kubicki, Marek Yeterian, Edward H. Makris, Nikos affil: Surgical Planning Laboratory, Brigham and Women′s Hospital, Harvard Medical School, 1249 Boylston, 02215, Boston, MA, USA sug: subj: Magnetic Resonance Imaging Neural Pathways Hand Language Tests Human Funding Source ab: The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. However, the representation of the entire CST and, specifically, the hand motor area has remained elusive. In this paper we propose a novel method, using manually drawn ROIs based on robustly identifiable neuroanatomic structures to delineate the entire CST and isolate its hand motor representation as well as to estimate their variability and generate a database of their volume, length and biophysical parameters. Using 37 healthy human subjects we performed a qualitative and quantitative analysis of the CST and the hand-related motor fiber tracts (HMFTs). Finally, we have created variability heat maps from 37 subjects for both the aforementioned tracts, which could be utilized as a reference for future studies with clinical focus to explore neuropathology in both trauma and disease states. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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