Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial.
Objective: Obstructive sleep apnea (OSA) is a high prevalent disorder with severe consequences including sleepiness, metabolic, and cardiovascular disorders. The aim of this study was to assess the effect of an individualized exercise-training (IET) program with educational sessions vs educational s...
| Publicado en: | Sleep Medicine Vol. 70; pp. 33 - 43 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Elsevier B.V.
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143658623&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143658623 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13899457 JJR jtl: Sleep Medicine issn: 13899457 maglogo: N pubinfo: dt: Jun2020 vid: 70 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 143658623 143658623 NLM32193052 143658623 10.1016/j.sleep.2020.02.008 NLM32193052 143658623 ppf: 33 ppct: 10 formats: tig: atl: Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial. aug: au: Bughin, F. Desplan, M. Mestejanot, C. Picot, M.C. Roubille, F. Jaffuel, D. Mercier, J. Jaussent, I. Dauvilliers, Y. affil: PhyMedExp INSERM U1046 / CNRS UMR9214, Montpellier University, Montpellier, University Hospital, France sug: subj: Therapeutic Exercise Sleep Apnea, Obstructive Therapy Disorders of Excessive Somnolence Sleep Apnea, Obstructive Diagnosis Adult Exercise Polysomnography Human Sleep, REM Comparative Studies Multicenter Studies Evaluation Research Validation Studies Randomized Controlled Trials Random Assignment Adult: 19-44 years ab: Objective: Obstructive sleep apnea (OSA) is a high prevalent disorder with severe consequences including sleepiness, metabolic, and cardiovascular disorders. The aim of this study was to assess the effect of an individualized exercise-training (IET) program with educational sessions vs educational sessions alone on severity markers of OSA over an eight-week duration.Methods: This was a randomised, controlled, parallel-design study. In sum, 64 patients with moderate-to-severe OSA (apnea-hypopnea index AHI 15-45/hour), low physical activity level (Voorrips<9), body-mass index (BMI) <40 kg/m2 were included in intervention group (IG) or control group (CG), and 54 patients finished the study. All underwent polysomnography (PSG), multiple sleep latency test (MSLT), constant workload exercise test, blood samples and fulfilled questionnaires twice. The primary endpoint was the change in apnea-hypopnea (AHI) at eight weeks from baseline. Main secondary endpoints were daytime sleepiness assessed by questionnaire and objective tests.Results: No significant between-group differences were found for changes in AHI. A reduction in AHI was found in IG only (p = 0.005). Compared to CG, exercise training leads to a greater decrease in AHI during REM sleep (p = 0.0004), with a significant increase in mean daytime sleep latency (p = 0.02). Between-group differences were significant for weight reduction, severity of fatigue, insomnia and depressive symptoms with trend for sleepiness symptoms.Conclusions: In adult patients with moderate-to-severe OSA, IET did not decrease AHI compared to the control group but improved markers of severity of OSA, in particular AHI in rapid eye movement (REM) sleep and objective daytime sleepiness. Adding personalized exercise training to the management of patients with OSA should be considered. CLINICALTRIALS.Gov Identifier: NCT01256307. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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