The morphological characteristics of hippocampus and thalamus in mesial temporal lobe epilepsy.
Background: Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsy, which is frequently characterized by hippocampal sclerosis (HS). Accumulating studies have suggested widespread cortico-cortical connections related to MTLE. The role of subcortical structures involved in gen...
| Publicado en: | BMC Neurology Vol. 20; no. 1; pp. 1 - 10 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
6/8/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143659411&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143659411 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712377 1CI7 jtl: BMC Neurology issn: 14712377 maglogo: N pubinfo: dt: 6/8/2020 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 143659411 143659411 NLM32513122 10.1186/s12883-020-01817-x NLM32513122 143659411 ppf: 1 ppct: 9 formats: tig: atl: The morphological characteristics of hippocampus and thalamus in mesial temporal lobe epilepsy. aug: au: Wu, Dongyan Chang, Feiyan Peng, Dantao Xie, Sheng Li, Xiaoxuan Zheng, Wenjing affil: Department of Neurology, China-Japan Friendship Hospital, 100029, Beijing, China sug: subj: Hippocampus Pathology Epilepsy, Temporal Lobe Pathology Epilepsy, Temporal Lobe Hippocampus Thalamus Thalamus Pathology Sclerosis Adult Young Adult Male Adolescence Female Magnetic Resonance Imaging Middle Age Questionnaires Scales Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Male Female ab: Background: Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsy, which is frequently characterized by hippocampal sclerosis (HS). Accumulating studies have suggested widespread cortico-cortical connections related to MTLE. The role of subcortical structures involved in general epilepsy has been extensively investigated, but it is still limited in MTLE. Our purpose was to determine the specific morphological correlation between sclerotic hippocampal and thalamic sub-regions, using quantitative analysis, in MTLE.Methods: In this study, 23 MTLE patients with unilateral hippocampal sclerosis and 24 healthy controls were examined with three-dimensional T1 MRI. Volume quantitative analysis in the hippocampus and thalamus was conducted and group-related volumetric difference was assessed. Moreover, vertex analysis was further performed using automated software to delineate detailed morphological patterns of the hippocampus and thalamus. The correlation was used to examine whether there is a relationship between volume changes of two subcortical structures and clinical characteristics.Results: The patients had a significant volume decrease in the sclerotic hippocampus (p < 0.001). Compared to controls, obvious atrophic patterns were observed in the bilateral hippocampus in MTLE (p < 0.05). Only small patches of shrinkage were noted in the bilateral thalamus (p < 0.05). Moreover, the volume change of the hippocampus had a significant positive correlation with that of the thalamus (P < 0.001). Intriguingly, volume changes of the hippocampus and thalamus were correlated with the duration of epilepsy (hippocampus: P = 0.024; thalamus: P = 0.022). However, only volume changes of thalamus possibly differentiated between two prognostic groups in patients (P = 0.026).Conclusions: We demonstrated the morphological characteristics of the hippocampus and thalamus in MTLE, providing new insights into the interrelated mechanisms between the hippocampus and thalamus, which have potential clinical significance for refining neuromodulated targets. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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