Prognostic Value of Prealbumin in Liver Cancer: A Systematic Review and Meta-Analysis.
Accumulated studies have reported the prognostic significance of prealbumin in liver cancer, but the results were not conclusive. The aim of this study was to evaluate the association between pretreatment serum prealbumin and clinical outcome of liver cancer patients through a meta-analysis. We comp...
| Publicado en: | Nutrition & Cancer Vol. 72; no. 6; pp. 909 - 917 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143696554&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143696554 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2020 vid: 72 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 143696554 143696554 143696554 10.1080/01635581.2019.1661501 143696554 ppf: 909 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prognostic Value of Prealbumin in Liver Cancer: A Systematic Review and Meta-Analysis. aug: au: Qiao, Weizhou Leng, Feng Liu, Tong Wang, Xuan Wang, Yueying Chen, Dongjie Wei, Jinlong affil: Department of Clinical Laboratory, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaoning, PR China sug: subj: Serum Albumin Liver Neoplasms Prognosis Human Systematic Review Meta Analysis Embase PubMed Cochrane Library Confidence Intervals Cancer Patients Descriptive Statistics Sensitivity and Specificity Publication Bias ab: Accumulated studies have reported the prognostic significance of prealbumin in liver cancer, but the results were not conclusive. The aim of this study was to evaluate the association between pretreatment serum prealbumin and clinical outcome of liver cancer patients through a meta-analysis. We comprehensively searched EMBASE, PubMed, Web of Science and the Cochrane library to identify eligible studies. The pooled hazard ratios (HRs) and their 95% confidence intervals (CIs) were utilized to evaluate the prognostic value of pretreatment serum prealbumin in overall survival (OS) and recurrence-free survival (RFS) of liver cancer patients. A total of 3470 patients from 10 eligible studies were finally included for analysis. The combined effects of prealbumin on liver cancer patients' OS and RFS were HR = 1.83, 95% CI: 1.46–2.30, P < 0.001 and HR = 1.47, 95% CI: 1.01–2.14, P = 0.045, respectively. Sensitivity and subgroup analysis showed that the pooled HR of prealbumin on liver cancer patients' OS was stable. Since potential publication bias was identified in the OS studies, the trim-and-fill method therefore was performed to explore publication bias, and the results showed reliability. This meta-analysis shows that low pretreatment serum prealbumin is significantly associated with poor prognosis of liver cancer patients. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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