Third-trimester in utero fetal brain diffusion tensor imaging fiber tractography: a prospective longitudinal characterization of normal white matter tract development.
Background: White matter is responsible for inter-neuronal connections throughout the brain that are a driving force in cognitive development. Diffusion tensor imaging (DTI) fiber tractography has been used to evaluate white matter development in the fetal brain; however, longitudinal studies of DTI...
| Publicado en: | Pediatric Radiology Vol. 50; no. 7; pp. 973 - 984 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=143700311&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 143700311 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Jun2020 vid: 50 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 143700311 143700311 NLM32399686 143700311 10.1007/s00247-020-04639-8 NLM32399686 143700311 ppf: 973 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Third-trimester in utero fetal brain diffusion tensor imaging fiber tractography: a prospective longitudinal characterization of normal white matter tract development. aug: au: Hooker, Jeffrey D. Khan, Majid A. Farkas, Amy B. Lirette, Seth T. Joyner, David A. Gordy, David P. Storrs, Judd M. Roda, Manohar S. Bofill, James A. Smith, Andrew D. James, Judy R. affil: Department of Radiology, University of Mississippi Medical Center, 2500 N. State St., 39216, Jackson, MS, USA sug: subj: Magnetic Resonance Imaging Methods Brain Embryology Pregnancy Trimester, Third Female Adult Prospective Studies Pregnancy Pilot Studies Human Funding Source Adult: 19-44 years Female ab: Background: White matter is responsible for inter-neuronal connections throughout the brain that are a driving force in cognitive development. Diffusion tensor imaging (DTI) fiber tractography has been used to evaluate white matter development in the fetal brain; however, longitudinal studies of DTI fiber tractography to assess white matter development in the third trimester are lacking.Objective: To characterize in utero longitudinal changes in the fetal brain DTI fiber tracts of normal third-trimester fetuses.Materials and Methods: For this single-center prospective longitudinal observational pilot study, we recruited 28 pregnant females with normal third-trimester pregnancies who had routine prenatal ultrasound. MRI of the in utero fetal brain was performed with a Siemens 1.5-tesla (T) Espree scanner at 31 weeks, 33 weeks and 36 weeks of gestation, with 14 DTI tractography parameters quantified in 7 brain regions using DTI-studio version 2.4 (Johns Hopkins University, Baltimore, MD; n=98 measurements). We used multilevel mixed models to examine the relationship between longitudinal changes in DTI measurements and between 98 DTI measurements at 31 weeks and 4 routine fetal brain anatomical biometrics (n=392 assessments).Results: We observed statistically significant decreases in radial diffusivity and apparent diffusion coefficient in 13 of 14 brain regions from 31 weeks to 36 weeks of gestation (P<0.001 for all regions except the genu of the corpus callosum). Significant decreases in radial diffusivity from weeks 33 to 36 and weeks 31 to 36 were seen in the corticospinal tracts, centrum semiovale, posterior limb of the internal capsule, and crus cerebri (P<0.001 for all). When considering all possible combinations of DTI fiber tract measurements and the routine morphological fetal brain biometrics, only 6% (24/392) had a significant association (P<0.05), indicating relative independence of the DTI fiber tract measurements from anatomical biometrics.Conclusion: In utero longitudinal changes in fetal brain DTI fiber tractography are quantifiable in normal third-trimester fetuses and are largely independent of morphological brain changes. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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